LEcture #60

  1. molality
    moles of solute/kg
  2. percent
    grams/100ml
  3. molarity
    moles of solute/liter
  4. osmolarity
    moles of dissociable solut particle/liter
  5. osmole
    amount of particles
  6. osmolality
    moles of dis solut paricle/kg fluid
  7. what is the osmolarity of 0.15M caCl2
    • 0.45 Osm
    • because there are 3 particles that dissociate
  8. what is significant about sugar?
    it does not dissociate
  9. what is the osmolairty of 142 mM NaCl + 5 mM KCl + 1 mM CaCl2 + 1 mM MgCl2
  10. what is the osmolairty of
  11. what is the osmolairty of 142 mM CaCl2 + 5 mM MgCl2 + 1 mM NaCl + 1 mM KCl?
  12. What is the osmolarity of a solution containing:
    – 50 mM NaCl + 5 mM KCl + 100 mM D-glucose?
  13. what are the body fluid compartments?
    • 3 of them
    • intracellular ( cytoplasm)
    • extracellular vascular ( plasma; fluid in vasculature)
    • extracellular extravascular ( fluid outside of vasculature but notinside cells)
  14. 60-40-20 rule
    • 60% of body weight is 
    • body water
    • intracellular 
    • extracellular
  15. what seperate the plasma from the interstital fluid?
    capillary walls
  16. pitting edema
    • too much fluid in the body
    • intersitial extravascular fluid compartment
    • usually on lower extremeties
  17. dehydration pinch test
    • pinch back of hand it does not bound back quickly mean pt is dehydrated
    • not enough fluid in interstitial
  18. what causes pitting edema
    • hypertension
    • increased vascular pressure forces fluid out into the the extravascular space
    • extra-vascular fluid pool in lower extremities
  19. what is one cause of hypertention in regard to kidney
    decrease kidney function thus kidney cannot filter those blood pressure increases
  20. how does water move in regard to concentration
    water moves into the direction of the higher solute concentration through a semipermeable membrane
  21. how does water move in regards to water chemical energy
    • water moves to eliminate  water chemical energy gradient
    • from higher water chemical gradient to lower
  22. formula for osmotic pressure
  23. normal concentation of NA+ and K+  in extracellular and intracellular space
    • 140mM Na, 5nM K
    • 20mM Na, 120mM K
  24. total osmolarity formula equals
  25. Which way will water move?
    – Intracellular osmolarity = 290 mOsm
    – Extracellular osmolarity = 590 mOsm
  26. Which way will water move?
    – Intracellular solution – 120 mM KCl, 20 NaCl, 20 mM Na2HPO4
    – Extracellular solution – 140 mM NaCl, 5 mM KCl, 10 mM
    NaH2PO4
  27. how does osmosis contribute to normal function of small intstine
    allows reabsoprtion of water
  28. reflection coefficent
    relative abiliity of solute to cross the cell membrane
  29. what does a reflection coefficent of 0 mean
    • the solute is freely permeable 
    • cannot drive net water movement
    • no osmotic pressure
  30. what does a reflection coefficent of 1 mean
    • impermeable
    • will drive water movement 
    • osmotic pressure
  31. what is reflection coefficent dependent one
    • the type of semipermeable membrane
    • the membrane can be permeable to just water, nacl , both, or there solutes.
  32. diffusion
    solutes move to to equalize concentration
  33. oncotic pressure
    osmotic pressure prduces by large marcomolecules , mainly proteins
  34. A patient receives an intravenous infusion of 2 L of solution A (200 mM
    NaCl, 5 mM KCl, 5 mM D-glucose). The blood concentrations are: 150
    mM NaCl, 5 mM KCl, 5 mM D-glucose. Which of the following will occur?
    • choose one:
    • Water will move from the interstitial fluid compartment into the vascular fluid
    • compartment
    • – Water will move from the vascular fluid compartment into the interstitial fluid
    • compartment
    • – NaCl will move from the interstitial fluid compartment into the vascular fluid
    • compartment
    • – NaCl will move from the vascular fluid compartment into the interstitial fluid
    • compartment
  35. all volume changes begin with..
    changes in the extracellulaer fluid compartment
  36. what happens if a pysican adds 1l of hypertonic salin solution to the body
    enter the extracellular fluid and triggers osmolarity to increase and volumes to increase then to level out osmolarity the water from the interstitial fluid will move across the cell membrane to the extra cellular fluid
  37. what happens if a physician adds 1l of hypotonic salin solution to the body
    enters extracellular fluid compartment where it increase the volume but decrease the osmolarity. water will move to the intracellular fluid comp to even out osmolarity resulting in the interstetial fluid having even more volune
  38. what happens if a physician adds 1l of isotonic salin solution to the body
    extra cellular volume increase molarity stays the same and there is not net driving force through the cell membrane
  39. what is the osmolarity of isotonic saline?
    .9%
  40. what is the normal cell osmolarity of NaCl?
    300mM NaCl
  41. example of a serous merocrine gland ? What does it do?
    • pancreas and partoid 
    • secrete mostly water
  42. example of a mucous merocrine gland ? What does it do?
    • sublingual and goblet cells 
    • glycoslytaed proteins
  43. example of a mixed (seromucos) merocrine gland ? What does it do?
    submandibular gland
  44. what percent of extracellular fluid is plasma?
    25%
  45. what percent of extracellular fluid is intersitial fluid?
    75%
  46. What does hypertonic volume contration mean?
    to lose hypotonic fluid
  47. what is a medical example of hypertonic volume contraction?
    • diabetes melittius
    • both ECF and ICF contract
  48. what clinically is an ex. of hypotonic volume contraction?
    addisions diseas lack of aldosterone
  49. what is hypotonic volume contraction
    • ECF contracts
    • ICF expands
    • you lose hypertonic fluid
  50. isotonic volume contraction medical example
    • losing blood
    • ECf contract ICf does not change 
    • to lose isotonic volume
  51. Isotonic volume expansion is the medical world is
    • isotonic saline IV
    • ECF changes ICF stays the same
  52. Hypertonic volume expansion
    • Hpertonic Saline IV
    • ECFexpands( inregard to volume and final movement of water ) , ICF contracts
  53. Hypotonic volume expansion
    ECF contract , ICF expands
  54. medical example of Hypotonic Vouem expansion
    Psycogenic polydipsia, SIADH
Author
Iana
ID
353237
Card Set
LEcture #60
Description
Physiology: Body Fluid Compartments
Updated