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Adenosine (Adenocard) dosing
6 mg rapid IV push (1-3 seconds) followed immediately by 20 ml bolus (NS) using a 3 way stopcock.
May repeat: 12 mg rapid IV push if no effect in 1-2 minutes.
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Adenosine (Adenocard) MOA
Slows conduction time through the AV node, interrupting the re-entry pathways through the AV node, restoring normal sinus rhythm.
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Adenosine (Adenocard) dose adjustments
- Carbamazapine - 3 mg initial dose
- Central line - 3 mg initial dose, 6 mg repeat dose
- Dipyridamole - 3 mg initial dose
- Heart transplant pt - 3 mg initial dose
- Theophylline - 12 mg initial dose.
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Adenosine (Adenocard) indications
- PSVT (paroxysmal supraventricular tachycardia)
- Regular and monomorphic wide-complex tachycardia
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Amiodarone (Cordarone) indications
- Cardiac arrest with recurrent VF/pulseless VT unresponsive to shocks, CPR, epi
- Hemodynamically stable VT
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Amiodarone (Cordarone) dosing (code)
VFib/Pulseless VT
- Initial dose - 300 mg rapid IV push
- May repeat - 150 mg if arrhythmia recurs
- May give undiluted
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Amiodarone (Cordarone) dosing after return of spontaneous circulation
- Initial dose - 1 mg/min IV x 6 hours
- Following with continuous infusion - 0.5 mg/min IV x 18 hours.
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Amiodarone (Cordarone) dosing for general ICU hemodynamically stable VT
- Initial dose - 150 mg IV over 10 min
- Follow with continuous infusion - 1 mg/min IV x 6 hours
- Follow with continuous infusion - 0.5 mg/min IV x 8 hours
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Amiodarone (Cordarone) MOA
Decrease AV conduction and sinus node function, prolongs action potential and refractory period in myocardial tissue
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Atropine sulfate indications
- Bradycardia
- Organophosphate poisoning
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Atropine sulfate dosing
- Initial dose - 0.5 mg IV push
- May repeat - 0.5 mg Iv push every 3-5 minutes
- Max 0.04 mg/kg or 3 mg total
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Calcium Chloride IV indications
- Severe hyperkalemia with cardiac manifestations
- Symptomatic hypocalcemia or hypermagnesemia
- Calcium channel blocker or beta blocker overdose with hypotension.
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Calcium Chloride IV dosing hypocalcemia, hyperkalemia, hypermagnesemia
- Initial dose: 0.5-1 gram IV over 10 minutes
- May repeat: 0.5-1 gram IV every 5 to 10 minutes
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Calcium Chloride IV dosing Calcium channel blocker/beta blocker toxicity
- Initial dose: 1 gram IV over 10 minutes
- May repeat: 1 gram IV every 2-3 minutes
- May follow with continuous infusion: when HR > 60
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Calcium Chloride IV doing continuous infusion
Usual dose: 20-40 mg/kg/hour IV (1-2 meq/kg/hr) (Dose is elemental calcium)
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Cisatracurium (Nimbex) indications
- Early acute respiratory distress syndrome (ARDS) with P/F ratios < 150
- Prevention of shivering during targeted temperature management
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Cisatracurium (Nimbex) dosing
- Initial dose: 3 mcg/kg/min IV
- Titrations: increase 1 mcg/kg/min IV every 15 minutes (Max 10 mcg/kg/min)
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Cisatracurium (Nimbex) compounding
Add 200 mg (20ml of 10mg/ml) to 480 mg NS of D5W. final concentration 0.4mg/ml
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Amiodarone (Cordarone) compounding
- Initial dose: add 150 mg to 100 ml D5W of NS
- Maintenance dose: add 900 mg to 500 ml D5W or NS
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Clevidipine (Cleviprex) indications
Hypertnesion
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Clevidipine (Cleviprex) dosing
- Initial: 2 mg/hour IV
- Titrations: Dose may be doubled every 90 seconds, as BP approaches goal, dose increases should be less than double and time between dose adjustments should be every 5-10 minutes
- Taper: decrease no faster than 1 mg/hr every 5-10 min as tolerated
- Max dose: 32 mg/hour
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Dexmedetomidine (Precedex) indications
- ICU sedation
- Alcohol withdrawal syndrome (AWS) when there is concern for respiratory depression with escalating doses of benzodiazepines
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Clevidipine (Cleviprex) dosing
- initial: 0.2 mcg/kg/hr IV
- Titrations: increase by 0.2 mcg/kg/hr IV every 30 minutes
- Max dose: 1.5 mcg.kg/hr
- Taper: decrease by 10% every 3 hours as tolerated
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Dextrose IV indications
- Hyperkalemia (when administered with insulin)
- Hypoglycemia
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Dextrose IV dosing hyperkalemia
Initial: 10 units regular insulin mixed in 50 ml D50W
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Diltiazem (Cardizem) IV indications
- Ventricular rate control in atrial fibrillation or flutter
- Refractory SVT after adenosine in pt with adequate blood pressure and narrow QRS complex
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Diltiazem (Cardizem) IV dosing Afib/Aflutter/SVT
- Initial: 15-20 mg (0.25 mg/kg) IV push over 2 minutes
- May repeat 20-25 mg (0.35 mg/kg) IV push over 15 minutes if needed
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Diltiazem (Cardizem) IV dosing continuous infusion
- Initial: 5 mg/hr
- Titrations: increase 5 mg/hr every 15 minutes to a target HR < 110
- Max dose: 15 mg/hr
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Diltiazem (Cardizem) IV compounding continuous infusion
125 mg (25 ml) to 100 ml NS of D5W
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