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Raven Neurology Review -9- Infectious Disease & Oncology

Home Get App Take Quiz Create Most common cause of bacterial meningitis in adults? Strep.Pneumo Common sequelae of bacterial meningitis? Hydrocephalus Epilepsy Hearing loss Major cause on meningitis in neonates? Group B Strep MRI changes in congenital CMV infection? Periventricular calcification What does congenital CMV cause? Sensorineural hearing loss Hepatosplenomegaly Petechiae Microcephaly What does congenital Toxo cause? Chorioretinitis, hydrocephalus, Scattered intracranial calcifications What does congenital rubella cause? Deafness Cataracts Cardiac malformations Most common cause of spinal cord dysfunction in AIDS? HIV mediated vacuolar myelopathy Most common cause of mono neuritis multiplex in AIDS? CMV What is coccidiomycosis? Common pulmonary fungal infection Will cause confusion and ataxia secondary to hydrocephalus TNF alpha MABs significantly increase your risk of it. Which fungal infection causes soap bubble cysts in the basal ganglia? Cryptococcus Which fungal infection causes haemorrhage strokes in post transplant patients? Aspergillosis Whats standard therapy for GBM? Surgery Radiotherapy Temozolamide Presence of which genetic mutation confers a favourable response to alkylating agents? MGMT hypermethylation Histologic feature of GBM? Pseudopallisading necrosis Anti-Hu antibody? From SCLC Sensory neuronopathy Cerebellar degen Limbic encephalitis Anti-TR antibody? Hodgkins lymphoma Cerebellar degeneration Anti-Yo antibody? Mostly ovarian and breast Cerebellitis Anti-Ta antibody? Testicular cancer Limbic encephalitis Anti-Ma2 antibody? Testicular and lung Limbic and brainstem encephalitis What is foster-kennedy syndrome? Olfactory groove tumors - lose sense of smell. Cause ipsilateral optic nerve atrophy Contralateral papilloedema What mutations are meningioma associated with? Mutations of the Merlin gene Which cell line do meningiomas arise from? Arachnoid Which is the most common primary brain tumour to haemorrhage? Oligodendroglioma Histology of ol-egg-odendrogliomas? Chicken wire capillaries Fried egg appearing cells Cytarabine side-effect? Acute cerebellar toxicity Pilocytic Astrocytomas? Cystic cerebellar lesion with an enhancing mural nodule Pilo means hair which represents the Rosenthal fibres on histology Respond well to treatment Ataxia-Telangectasia AR Due to mutation in ATM gene responsible for DNA repair Sensitive to radiotherapy Have an Immunoglobulin deficiency so they get sinopulmonary infections Increased risk of leukaemia and lymphoma Subependymal giant cell astrocytomas (SEGA) are typical for what? Tuberous sclerosis Most common location for a DNET? Temporal lobe Which variant of ependymomas arises from the filum terminale? Myxopapillary ependympoma Common haemorrhage mets? Melanoma Renal Thyroid Choriocarcinoma What cancer is Anti-ampiphysin assoc with? Breast mainly then lung Most common tumor associated with GABA-a? Thymoma 2 most common causes for leptomeningeal mets? Breast Lung Glial neoplasm with necrosis and pseudopallisading nuclei GBM "Fried egg" appearance Oligodendroglioma (fixation artefact) Perivascular pseudorosettes Ependymoma True Rosettes Ependymoma Homer-Wright Rosettes Medulloblastoma Ki-67 Marker of nuclear proliferation GFAP Marker of glial intermediate filaments Cytokeratin Marker of epithelial intermediate filaments Rosenthal Fibres Pilocytic astrocytomas Pleomorphic xanthoastrocytoma Alexander Disease Chromosome 1p and 19q deletion Good prognostic factor in ODG Where do Brain mets arise from? Lung>Breast>melanoma Tumors typically presenting with seizures? ODG Gangliomas DNETs Anti-Ri? Opsoclonus myoclonus Breast, lung and ovarian Posterior fossa tutor with drop mets? Medulloblastoma Radiological features of gangliomas? Often in temporal lobes with cystic component. What differentiates a dermoid from an epidermoid? Dermoids and teratomas have all sort fo tissue in them so they have a heterogenous internal sinal. Epidermoid cysts are lined with squamous cells and are homogenous. What is a dandy walker malformation A posterior fossa cyst that communicates with the 4th ventricle. Severe atrophy of the vermis What differentiates GBM from lymphoma on MR? Lymphoma  - Avid + homogenous enhancement NEAR CSF spaces GBM - Heterogenous enhancement, situated peripherally. Commonest intracranial tumor? Mets Then Meningioma, GBM, pituitary microadenomas Whats the relevance on HHV 6? Often comes out to play after bone marrow or solid organ transplant Usually causes a limbic encephalitis Can cause myelitis or leukoencephalopathy What percentage of patients with confirmed HSV have plum normal CSF? 5% What is Lemierre's syndrome? Primary oropharyngeal, tonsillar or peritonsillar inflammation With later development of sepsis, internal jugular vein thrombosis and septic emboli. This is typically caused by the bacterium Fusobacterium necrophorum. GabaA encephalitis Often presents in status/NORSE multifocal T2 lesions Which neoplasia is Morvan's most strongly associated with? Thymoma How long do you give dexamethasone for pneumococcal meningitis? 4 days What is intracranial germinoma? Homogenous, avidly enhancing, extra axial mass on or near the pineal. Often presents in young male Don't do surgery, you'll spread it everywhere - radiology works very well for it. How would you manage cryptococcal meningitis? IV Amphoterocin Oral flucytosine (better than fluconazole) Daily LPs to drop ICP Start antiretroviral 10-14 days after start of anti-fungal

Author vb406 ID 350984 Card Set Raven Neurology Review -9- Infectious Disease & Oncology Description neurology revision Updated 2020-11-15T08:54:40Z Show Answers