-
Typical/ Atypical: chlorpromazine?
typical (low potent)
-
Typical/ Atypical: thioridazine?
typical (low potent)
-
Typical/ Atypical: haloperidol?
typical (high potent)
-
Typical/ Atypical: pimozide?
typical (high potent)
-
Typical/ Atypical: fluphenazine?
typical (high potent)
-
Typical/ Atypical: perphenazine?
typical (mod potent)
-
Typical/ Atypical: molindone?
typical (mod potent)
-
Typical/ Atypical: loxapine?
typical (mod potent)
-
Typical/ Atypical: trifluoperazine?
typical (mod potent)
-
Typical/ Atypical: thiothixene?
typical (mod potent)
-
Typical antipsychotics may most likely worsen ______ (positive/negative) symptoms
negative
-
T/F: typical antipsychotics block D2 receptors and serotonin receptors
false; atypicals block those two, typical only D2
-
Mesolimbic tract: function and problems in schizophrenia
- function- emotions
- schizophrenic patients often have too much dopamine here leading to positive symptoms
-
Mesocortical tract: function and problems in schizophrenia
- functions- executive functions, thinking and memory
- in pt with schizophrenia, too little DA in this area leading to negative symptoms
-
Nigrostriatal and tuberoinfundibular tracts functions
- Nigrostriatal- voluntary movement and balances acetylcholine
- Tuberoinfundibular- regulates prolactin
-
when mesolimbic tract has too much dopamine, it could lead to ___ symptoms
positive
-
when _____ tract has too little dopamine, it could lead to negative symptoms
mesocortical
-
Typical/ Atypical: aripiprazoel (abilify)
atypical
-
Typical/ Atypical: asenapine
atypical
-
Typical/ Atypical: brexpiprazole
atypical
-
Typical/ Atypical: cariprazine
atypical
-
Typical/ Atypical: clozapine
atypical
-
Typical/ Atypical: iloperidone
atypical
-
Typical/ Atypical: lurasidone
atypical
-
Typical/ Atypical: olanzapine
atypical
-
Typical/ Atypical: paliperidone
atypical
-
Typical/ Atypical: quetiapine
atypical
-
Typical/ Atypical: risperidone
atypical
-
Typical/ Atypical: ziprasidone
atypical
-
what is the drug used to treat hallucinations and delusions associated with Parkinson's disease psychosis
pimavanserine
-
Pimavanserine does not have D2 block in _____ tract, therefore it is use to treat _____
- nigrostriatal
- hallucinations a/w Parkinson's disease
-
most antipsychotics ADRs are associated with typical antipsychotics, except for _____, which is most commonly seen with atypical antipsychotics use
metabolic syndrome (weight gain)
-
What EKG changes can be seen with antipsychotic use:?
prolonged QT
-
A rare but life threatening adverse effect a/w antipsychotic use is:
neuroleptic malignant syndrome
-
what is neruleptic malignant syndrome?
confusion, hyperthermia, rigidity, similar to serotonin syndrome
-
Side effects that are unique to clozapine use?
- constipation
- higher sz risk
- agranulocytosis
- sialorrhea
-
Agranulocytosis is a side effects most likely a/w _____.
clozapine (along with seizures, myocarditis, and other cardiac and respiratory effects)
-
Smokers should have higher dosages when taking ____ and _____, because smoking induces CYP ____
- clozapine and olanzapine
- CYP 1A2
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