-
When detrusor muscle is relaxed, what is going on in the bladder?
Urine filling
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Detrusor muscle relaxation is under which branch of the autonomic?
sympathetic
-
Detrusor muscle contraction, what goes on in the bladder?
voiding
-
Detrusor muscle contraction is under which branch of the autonomic control?
Parasympathetic
-
Cholinergic effect is associated with ______ nervous system
parasympathetic
-
What are cholinergic effects?
- Diarrhea
- Urination
- Miosis (pupil constriction), muscle weakness
- Bronchospasm
- Bradycardia
- Excitation
- Lacrimation
- Salivation, sweating, seizures
-
Urination is when detrusor muscle _____ and sphincter _____
- Contract (detrusor)
- Relax (sphinctor)
-
Anticholinergic side effects:
- Dry mouth
- Confusion
- Constipation
- Blurred vision
- Urinary retention in male
-
Antimuscarinic has ______ effects
Anticholinergic
-
What is the MOA of antimuscarinic?
Prevent Ach from binding to M3 receptor (muscarinic receptor)
-
What are agents of antimuscarinics
-
First line treatment for urinary retention is ____
Antimuscarinic use
-
______ is an antimuscarinic that can come in transdermal gel/patch form, _____ is antimuscarinic that is only taken orally but has lesser ADR
-
ADR of antimuscarinics?
- dry mouth
- Constipation
- Blurry vision
-
What is a C/I of antimuscarinics
Narrow-angle glaucoma
-
Narrow-angle glaucoma is a contraindication for which drug?
Antimuscarinics
-
Which drug has the MOA that prevents release of acetylcholine?
Botulinum toxin A
-
Botulinum toxin A causes _____ of the detrusor muscle
Relaxation
-
When anticholinergic drug is inadqueate in treating urinary incontinence, use ____
Botulinum toxin A
-
ADR of botulinum toxin A?
- Urinary tract infections
- Urinary retention
-
Which drug has the MOA that is a beta 3 agonist?
Mirabegron
-
What is the MOA of mirabegron?
Beta-3 agonist in the bladder which relaxes detrusor muscle
-
Which drug has adverse effect of hypertension and angioedema?
Mirabegron
-
What is the c/I in mirabegron?
Hypersensitivity
-
ADR of mirabegron?
- Hypertension
- Nasopharyngitis
- Urinary tract infection
- Headache
- Angioedema
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