Abortifacient Pharmacology

  1. What drugs are used for medical abortion?
    • Mifepristone 200 mg
    • Misoprostol 800 microgram
  2. Which drug is a progesterone receptor antagonist?
  3. What happens to the endometrium (decidua) with mifepristone use?
    Blockade of progesterone action by mifepristone results in decay and death of the decidua
  4. What is the MOA of misoprostol?
    Stimulates uterine contraction
  5. Misoprostol is a ________ (type of drug)
    Synthetic analog of PGE1
  6. What are uses of misoprostol?
    • Used for acid-peptic disease as it stimulates prostaglandin receptors on parietal cells to decrease gastric acid secretion
    • OB Use- as abortifacient, ripen cervix prior to labor, induce labor and treat postpartum hemorrhage
  7. ADR of misoprostol?
    • Diarrhea
    • Abdominal cramping
    • Flatulence
  8. Stimulate prostaglandin receptor will ________
    Cause myometrium contraction
  9. Which prostaglandins cause uterine contraction?
    E1, E2 and F2 alpha
  10. Analogs of PGE1 is _______, PGF2alpha is ______ and PGE2 is _____
    • Misoprostol
    • Carboprost
    • Dinoprostone vaginal suppository
  11. Treatment of postpartum hemorrhage due to uterin atony, use _____ to treat
    Carboprost (PGF2 alpha analog)
  12. ______ is indicated for evacuation of the uterin content in the management of missed abortion or intrauterine fetal death
    Dinoprostone (analog of PGE2)
  13. Misoprostol for OB use, routes of administration include_____, ______ and _____
    • Orally
    • Vaginally
    • Rectally
Card Set
Abortifacient Pharmacology
Endo Final