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What drugs are used for medical abortion?
- Mifepristone 200 mg
- Misoprostol 800 microgram
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Which drug is a progesterone receptor antagonist?
Mifepristone
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What happens to the endometrium (decidua) with mifepristone use?
Blockade of progesterone action by mifepristone results in decay and death of the decidua
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What is the MOA of misoprostol?
Stimulates uterine contraction
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Misoprostol is a ________ (type of drug)
Synthetic analog of PGE1
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What are uses of misoprostol?
- Used for acid-peptic disease as it stimulates prostaglandin receptors on parietal cells to decrease gastric acid secretion
- OB Use- as abortifacient, ripen cervix prior to labor, induce labor and treat postpartum hemorrhage
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ADR of misoprostol?
- Diarrhea
- Abdominal cramping
- Flatulence
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Stimulate prostaglandin receptor will ________
Cause myometrium contraction
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Which prostaglandins cause uterine contraction?
E1, E2 and F2 alpha
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Analogs of PGE1 is _______, PGF2alpha is ______ and PGE2 is _____
- Misoprostol
- Carboprost
- Dinoprostone vaginal suppository
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Treatment of postpartum hemorrhage due to uterin atony, use _____ to treat
Carboprost (PGF2 alpha analog)
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______ is indicated for evacuation of the uterin content in the management of missed abortion or intrauterine fetal death
Dinoprostone (analog of PGE2)
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Misoprostol for OB use, routes of administration include_____, ______ and _____
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