Clomiphene/Infertility Pharmacology

What is MOA of clomiphene?

Weak partial agonist at estrogen receptors, acts mainly by inhibiting action of stronger estrogens at estrogen receptors (basically end up being an estrogen blocker by blocking the strong estrogens like estradiol from binding to the receptors)
What can clomiphene be used to treat?

PCOS
Elimination half life of clomiphene?

5-7 days
Clomiphene blocks ______ estrogen receptors, thus inhibiting _____ negative feedback on the hypothalamus causing an ____ secretion of GnRH and therefore, FSH and LH
- Hypothalamic
- Estradiol
- Increase
What is the therapeutic result with clomiphene use?

Stimulate ovulation
What is the timing of clomiphene use?

Given cyclically during menstrual cycle until ovulation is induced
Clomiphene treatment typically begins with ____mg tablet daily for _____ consecutive _____, increasing by ____ mg increments in subsequent cycles until _____ is induced.
- 50
- Five
- Days
- 50
- Ovulation
Which two hormones would rise with clomiphene use?

FSH and LSH would rise and fall after the typical 5 day cycle is completed
How would you know when the clomiphene treatment is successful?

One or more dominant follicle would emerge and mature thereby generating RISING ESTRADIOL levels that ultimately trigger the mid-cycle LH surge and ovulation

Author

lykthrnn

349709

Card Set

Clomiphene/Infertility Pharmacology

Description

Endo Exam 4

Updated

2019-11-24T20:35:56Z

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