Dysmenorrhea Pharmacology

What are treatments used to treat primary dysmenorrhea?
- Oral contraceptive (estrogen and progestin)
- NSAID (prostaglandin synthase inhibitor)
What is the mechanism of action of OCP?

prevent production of menstrual prostaglandin by decreasing the growth of the endometrial lining
Prostaglandin is released during _________

Menstruation (which mediate the main symptoms in primary dysmenorrhea)
Which COX enzyme can generate cytoprotective prostaglandins?

COX-1 – generates prostacyclin PGE2, increase GI tract resistant to acid
Which COX enzyme is involved in platelet aggregation?

COX-1 (TXA2)
Which COX enzyme is induced by TNFalpha, IL-1 and others?

COX-2
What drug inhibits production of uterine prostaglandin?

NSAID
T/F: Ibuprofen and naproxen inhibits COX 1 only

False; it selective for COX1 and COX2
Adverse effect of NSAID:

Gastric ulceration and acute renal failure
T/F: NSAID anaphylactoid reaction may occur in patients without prior exposure to etodolac

True; etodolac should not be given to patients with aspirin triad
What is the aspirin triad?
- Allergic rhinitis
- Nasal polyps
- Asthma
Aspirin exacerbated respiratory disease (AERD) and aspirin-exacerbated cutaneous disease (AECD) are hypersensitivity reaction with ____ use

NSAID
T/F: hypersensitivity to NSAID occurs because of increased leukotrienes pathway due to inhibition of COX

True
T/F: there can be cross-sensitivity allergic reactions to the NSAIDS

True s

Author

lykthrnn

349455

Card Set

Dysmenorrhea Pharmacology

Description

Endo Exam 3

Updated

2019-11-08T21:26:56Z

Show Answers