T/F: suprachiasmatic nucleus is the master controller found in the anterior pituitary
False; it is found in the anterior HYPOTHALAMUS, not the anterior pituitary
T/F: more cholesterol is produced at night, so take statins at night
True
What’s Zeitgebers?
Any external or environmental cue (i.e light, temperature, food availability, social interactions) that entrains or synchronizes an organisms biological rhythms to the Earth’s 24 hour cycle
Strong circadian rhythm would reflect a ____ TSH secretion curve
Sinusoid
What color wavelength of light is best at resetting our circadian rhythm daily?
Blue
T/F: being outside on a rainy day provides less lux than being in your room with all the lights on
False; outside has more lux in general, regardless rain or shine
Spending most of our day indoors and our evenings with artificial lighting can _______ our circadian rhythm
Weaken
Adenosine level _____ during sleep
Decreases
What is adenosine?
It builds up throughout the day in the brain, it is “sleep pressure”
What is the role of caffeine in relation to adenosine?
caffeine is adenosine receptor blocker, so tricks the brain in thinking there is no adenosine so you don’t feel the sleep pressure
Blue light is absorbed by the ____ in the eye light pathway
Retina
Blue light has what effect on the pineal gland?
Inhibits it form releasing melatonin
Melatonin would ____ heat loss, ____ arousal and related brain activity, and ______cortisol production
Induce
Reduce
Delays (cortisol is low at night, I’m guessing its because of this)
Fed state would ____ growth hormone
Inhibit
Long term cortisol would have what effect on glucose tolerance?
Decrease glucose tolerance
Higher risk of diabetes
Long term cortisol contributes to :
Decreased glucose tolerance
Increased dyslipidemia
Increased blood pressure
Depression
Anxiety
Cognitive dysfunction
Fat breakdown, gluconeogenesis, glycogenolysis occurs during ________
Sleep/fasting
(Brain needs food during this time)
Lose sleep would ____ ghrelin, ____ leptin and result is ____(eating habit)
Increased
Decreased
Overeating
T/F: breast cancer is studied to have 20% higher incidence rates in people with exposure to light at night
True; again, we are all going to die of cancer according to Bansal, should not be surprised that this is true
What role does melatonin play when it comes to DNA repair and signal transduction?
Stimulate DNA repair
Inhibits tumor signal transduction and metabolic activity of cancer cells
T/F: melatonin is a significant scavenger of reactive oxygen species
True
When are NK cells most active?
They are most active in the dark and are key to preventing turmor formation
You should go to be _____ after dark
3-4 hours
When is the best time to eat dinner?
3 hours before bed
(the idea is that Growth hormone is high at night, so if go to bed completely full then GH wont be secreted, if there is some hunger, then growtha hormone would get secreted)
