Drugs & Behavior TEST 1

  1. passive transport mechanism
    the non lipid soluble molecule attaches itself to a carrier molecule in the membrane.
  2. active transport mechanism
    similar to a passive mechanism except that it can work against normal diffusion by concentrating a substance on one side of a membrane.
  3. Metabolism
    all of the chemical processes in the body related to the production and utilization of energy (aka biotransformation)
  4. catabolism
    complex chemical compounds are broken down into similar ones (releases energy)
  5. anabolism
    simple chemical compounds are built up into more complex one (requires energy)
  6. liver
    the most active tissues in metabolism
  7. hepatic system
    drug molecules cross the membranes of the cells in the GI tract, they move into a blood circulation system that goes directly to the liver before getting into the blood that supplies the body and brain , to be further metabolized in the liver
  8. first-pass metabolism
    why plasma of brain concentrations of drugs administered in this fashion are generally lower than those of drugs administered through other routes
  9. by far the organ most responsible for metabolizing drugs is the
  10. hepatic microsomal enzyme system
    a large complex of enzymes that exists within the membranes of the primary liver cells.
  11. drug metabolizing enzymes
  12. tolerance
    refers to a decreased effectiveness of a drug with repeated administration
  13. enzyme induction
    levels of a given enzyme can be increased by previous exposure to a specific drug which uses that enzyme or some other drug that uses that enzyme or system
  14. metabolic tolerance
    increased enzyme activity
  15. Antabuce (disulfiram)
    is a drug which conpetes with acetaldehyde for this enzyme and this meand that acetaldehyde levels increase in the body because the enzyme is not readily available to metabolize it.
  16. Renal or Kidney excretion
    of drugs (primarily their metabolites) is the primary way in which they are removed from the body
  17. lipid solubility
    to a great extent what the metabolites depend oon is the rate of the excretion.
  18. placenta
    the organ connected to the fetus that attaches to the wall of the uterus.
  19. teratogenic effects
    abnormal development
  20. teratogenic effects
    longterm behavioral effects
    direct toxic effects
    the risk to the fetus include
Card Set
Drugs & Behavior TEST 1
quiz 3