Cholesterol desmolase (aka cholesterol sidechain cleaving enzyme) is expressed from gene ______, and cleaves carbon _____
CYP11A
20
T/F: CYP450 oxidize many different compounds including cholesterol
True
Cholesterol has ____ carbons, progestogens, mineralocorticoids and glucocorticoid have ____ carbons, androgens with ____ carbons and estrogen _____ carbons
27
21
19
18
21-hydroxylase deficiency will cause abnormality in which electrolyte?
Na+, this will cause salt wasting because of deficiency in mineralocorticoids which would lead to inadequate regulation of salt and excessive sodium will be lost in urine
21-hydroxylase deficiency will in turn lead to increased in _____ and _____
Progesterone (just upstream of mineralocorticoids synthesis)
Androgen
T/F: Androgen is made via the 17’s and mineralocorticoid and glucocorticoid are made via the 21’s
True
21-hydroxylase deficiency, will have deficiency in _____ and ____
Aldosterone
Cortisol
____ link an alcohol at C21, _____ lyses the bond between C17-C20, ______ forms aromatic ring by oxidizing
21-hydroxylase
17-20 lyase
Aromatase
Micropenis, ambiguous genitalia, gynecomastia can be seen in males who lack ___
3 beta dehydrogenase (causes virilization in males)
(21 hydroxylase deficiency can cause excessive virilization)
