Adrenal Pharmacology

Two main pharmacological purposes of cortisol:

When there is adrenal insufficiency, use ______ to treat

When someone is having an inflammation/immune response, ie arthritis, asthma, use _____ to treat

T/F: 90% of cortisol in the body is free floating and can easily cross through membrane of target cells
True False

T/F: cortisol inhibits macrophages from secreting inflammatory cytokines
True False

T/F: there is an immediate anti-inflammatory response with the use of cortisol
True False

T/F: there is a rapid immediate response of vasoconstriction with cortisol use
True False

Mineralocorticoid is a fancy name for _____, and they act on the _______ and allows for _______

T/F: mineralocorticoid receptor can be activated by cortisol
True False

_____ converts cortisone (inactive) to cortisol (active) in the _____. Cortisol then go to the ____, which ____ converts it back to cortisone

Compound F is another name for _____

Short-to-medium acting glucocorticoid agents include:

Most glucocorticoid can be given ___

Long acting glucocorticoid agent include:

What is an agent of mineralocorticoids (the answer is not aldosterone):

T/F: Prednisone is an active form of glucocorticoid with carbonyl group at the 11th Carbon
True False

Active forms of glucocorticoid/ mineralocorticoid have _____ group at carbon position 11. These include:

In Addisons disease, there is a ____ in mineralocorticoid, and ____ in glucocorticoid, resulting in symptoms such as ___, ____ and ______

What is the standard therapy for treating Addisons?

T/F: diabetes can result as a side effect of glucocorticoid use
True False

What are adverse effects of corticosteroid?

What are ways to limit corticosteroid adverse effects?

What can happen to the zona fasciculata and zona reticularis with secondary adrenal insufficiency?

T/F: acquired secondary adrenal insufficiency is a common clinical problem and is most often caused by a sudden cessation of exogenous glucocorticoid therapy
True False

Secondary adrenal insufficiency should be anticipated if on glucocorticoid treatment for longer than _______

When there is adrenal suppression from long term corticosteroid use, recovery from that may take up to _____ months. _____ level will return to normal faster because CRH recovers within weeks, however, _____ will take longer

Cushings syndrome will have these clinical symptoms:

Cushing syndrome is likely when ________ test result is _______. So then you run _____ level.

T/F: fetal aldosterone is important in lung maturation
True False

Betamethasone acetate is used for _____