Coagulation Factors Classified by their Physical Properties

• Factor XI
• Factor XII
• Prekallikrein (PK)
• Kininogen (HMWK)

involved in initial phase of intrinsic system activation

• usually asymptomatic
• except XI deficiency which usually results to a mild bleeding disorder

thrombosis

• Factor II
• Factor VII
• Factor IX
• Factor IX
• Factor X
• Protein C
• Protein S
• Protein Z

gamma - carboxyglutamic acid

critical for Factor IV (Ca2+) to bind to platelet phospholipid surface

Vitamin K dependent

Vit K dependent clotting factors

required for carboxylation of glutamic acid residues

stable and preserved in stored plasma

• Warfarin 
• Coumadin

inhibit the Vitamin K dependent carboxylation of glutamic acid

Factors are still produced but are nonfunctional

body doesn't store Vit K because it is produced in equilibrium levels by normal flora in gut

deficiencies may be due to surgery, IV antibiotics, liver disease

liver

• endothelial cells
• megakaryocytes

• Factor I
• Factor V
• Factor VIII
• Factor XIII

thrombin sensistive clotting factors that consist of high molecular weight proteins

• Factor V
• Factor VIII: anti haemophiliac A Factor

• plasma 
• platelets