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Coagulation Factors Classified by their Physical Properties
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What are the Contact Proteins for Coagulation Factors
Factor XI
Factor XII
Prekallikrein (PK)
Kininogen (HMWK)
what is the function of contact proteins
involved in initial phase of intrinsic system activation
deficiency in contact proteins leads to what (what protein deficiency is the exception)
usually asymptomatic
except XI deficiency which usually results to a mild bleeding disorder
Factor XII and prekallikrein deficiencies leads to what
thrombosis
what are the factors in prothrombin group?
Factor II
Factor VII
Factor IX
Factor IX
Factor X
Protein C
Protein S
Protein Z
What is the unique component in the prothrombin group
gamma - carboxyglutamic acid
what is the importance of gamma carboxyglutamic acid in prothrombin group?
critical for Factor IV (Ca2+) to bind to platelet phospholipid surface
What molecule is required for prothrombin group proteins
Vitamin K dependent
prothrombin group is also known as
Vit K dependent clotting factors
What is the importance of Vit K for prothrombin group
required for carboxylation of glutamic acid residues
Is the prothrombin group stable or unstable in stored plasma
stable and preserved in stored plasma
what are the antagonists to Vitamin K
Warfarin
Coumadin
What does Warfarin and Coumadin do?
inhibit the Vitamin K dependent carboxylation of glutamic acid
What does the lack of Vit K do for the proteins in prothrombin group?
Factors are still produced but are nonfunctional
Describe how acquired deficiencies of Vit K coagulation factors can occur
body doesn't store Vit K because it is produced in equilibrium levels by normal flora in gut
deficiencies may be due to surgery, IV antibiotics, liver disease
what organ produces most of the coagulation factors?
liver
where is vWF produced
endothelial cells
megakaryocytes
What are the factors in the Fibrinogen Grouop
Factor I
Factor V
Factor VIII
Factor XIII
fibrinogen group are also called
thrombin sensistive clotting factors that consist of high molecular weight proteins
what are the least stable (labile) factors in fibrinogen group
Factor V
Factor VIII
: anti haemophiliac A Factor
Where are the firbinogen group proteins found in
plasma
platelets
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Author
tanyalequang
ID
348858
Card Set
Coagulation Factors Classified by their Physical Properties
Description
coagulation factors
Updated
2019-10-10T01:10:47Z
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