Coagulation Factors Classified by their Physical Properties

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What are the Contact Proteins for Coagulation Factors
- Factor XI
- Factor XII
- Prekallikrein (PK)
- Kininogen (HMWK)
what is the function of contact proteins

involved in initial phase of intrinsic system activation
deficiency in contact proteins leads to what (what protein deficiency is the exception)
- usually asymptomatic
- except XI deficiency which usually results to a mild bleeding disorder
Factor XII and prekallikrein deficiencies leads to what

thrombosis
what are the factors in prothrombin group?
- Factor II
- Factor VII
- Factor IX
- Factor IX
- Factor X
- Protein C
- Protein S
- Protein Z
What is the unique component in the prothrombin group

gamma - carboxyglutamic acid
what is the importance of gamma carboxyglutamic acid in prothrombin group?

critical for Factor IV (Ca2+) to bind to platelet phospholipid surface
What molecule is required for prothrombin group proteins

Vitamin K dependent
prothrombin group is also known as

Vit K dependent clotting factors
What is the importance of Vit K for prothrombin group

required for carboxylation of glutamic acid residues
Is the prothrombin group stable or unstable in stored plasma

stable and preserved in stored plasma
what are the antagonists to Vitamin K
- Warfarin
- Coumadin
What does Warfarin and Coumadin do?

inhibit the Vitamin K dependent carboxylation of glutamic acid
What does the lack of Vit K do for the proteins in prothrombin group?

Factors are still produced but are nonfunctional
Describe how acquired deficiencies of Vit K coagulation factors can occur

body doesn't store Vit K because it is produced in equilibrium levels by normal flora in gut

deficiencies may be due to surgery, IV antibiotics, liver disease
what organ produces most of the coagulation factors?

liver
where is vWF produced
- endothelial cells
- megakaryocytes
What are the factors in the Fibrinogen Grouop
- Factor I
- Factor V
- Factor VIII
- Factor XIII
fibrinogen group are also called

thrombin sensistive clotting factors that consist of high molecular weight proteins
what are the least stable (labile) factors in fibrinogen group
- Factor V
- Factor VIII: anti haemophiliac A Factor
Where are the firbinogen group proteins found in
- plasma
- platelets

Author

tanyalequang

348858

Card Set

Coagulation Factors Classified by their Physical Properties

Description

coagulation factors

Updated

2019-10-10T01:10:47Z

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