-
Phenobarbital
- Luminal
- MOA: enhance GABAa
-
Phenytoin
- Dilantin
- MOA: motor cortex - block Na and Ca
-
Primidone
- Mysoline
- pro-drug of phenobarbital
-
Ethosuximide
- Zarontin
- MOA: block T-type calcium channels
-
Carbamazepine
- Tegretol
- MOA: inhibit Na channels
-
Valproate
- Depakote
- MOA: increase GABA, inhibit Na channels
-
Felbamate
- Felbatol
- MOA: inhibits Na channels
-
Lamotrigine
- Lamictal
- MOA: inhibit Na channels, inhibits glutamate
-
Gabapentin
- Neurontin
- MOA: modulate Ca channels, may increase GABA
-
Topiramate
- Topamax
- MOA: block Na, glutamate, Ca, release GABA mediated chloride opening, inhibit carbonic anhydrase, increase potassium conductance
-
Tiagabine
- Gabitril
- MOA: blocks reuptake of GABA via inhibition of GAT transporter
-
Levetiracetam
- Keppra
- MOA: SV2A blocking vesicle release
-
Oxcarbazepine
- Trileptal
- MOA: block Na channels
-
Zonisamide
- Zonegran
- MOA: inhibit Na and Ca, weak carbonic anhydrase inhibitor
-
Pregabalin
- Lyrica
- MOA: modulate Ca channels, may increase GABA
-
Lacosamide
- Vimpat
- MOA: first to enhance slow inactivation of Na channels
-
Rufinamide
- Banzel
- MOA: modulate NMDA receptor to reduce glutamatergic transmission, block Na and Ca
-
Vigabatrin
- Sabril
- MOA: irreversible inhibtor of GABA-T
-
Clobazam
- Onfi
- MOA: bind to GABAa to potentiate
-
-
Eslicarbazepine
- Aptiom
- MOA: enhance slow inactivation of Na and Ca
-
-
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