Lymphoma Genetics

  1. What are lymphomas?
    Cancers that develop from lymphocytes, forms a mass in the lymph nodes
  2. What is most common cell type involved in lymphomas?
    B cells
  3. T/F: Hodgkins lymphomas are the most common type of lymphoma, accounting for 90% of all lymphomas
    False; it is non-hodgkins lymphoma that is the most common
  4. EBV is often involved in which non-hodgkin lymphoma(s)?
    • Burkitt lymphoma
    • 10-15% cases of Diffuse Large B cell lymphoma
  5. Burkitt and follicular lymphoma arise from ______. Mantle cell lymphoma arises from ______. Diffuse large B cell lymphoma arises from_______. And multiple myeloma (not a lymphoma) arises from______.
    • Germinal center B cells
    • Naïve mature B cells (one step before germinal center reaction)
    • Plasmablast
    • Plasma cell
  6. Which of the non-hodgkin lymphoma is the most common one?
    • Diffuse large B cell lymphoma
    • These are aggressive but potentially curable
  7. Which NHL can develop in extranodal sites?
    • Diffuse large B cell lymphoma
    • Burkitt lymphoma (in child especially)
  8. T/F: NHL B cells all express CD 15 and CD 30
    False; B cells are CD20 +; CD15+ and CD30+ is classically for hodgkins lymphoma
  9. What are the Heavy Chain NHL? What does Heavy chain mean?
    • Burkitt
    • Follicular
    • Mantle Cell
    • Heavy chain – IGH (immunoglobulin heavy chain) on Chromosome 14 is strong and leads to higher transcription levels, so with translocation of genes to this site it generates oncogene proliferation
  10. Proliferations of Cyclin-D1 is _________, c-Myc is ________ and BCL-2 is _______
    • Mantle cell lymphoma (clyclinD1)
    • Burkitt lymphoma (c-Myc)
    • Follicular lymphoma (BCL2)
  11. T(14;18) is ______, which means overexpression of _________ and its function is ________
    • Follicular lymphoma
    • BCL2
    • To stop apoptosis.
  12. T(11;14) is _______, which means overexpression of_______ and its function is ________
    • Mantle cell lymphoma
    • CyclinD1
    • Promote G1/S transition in the cell cycle facilitating neoplastic proliferation
  13. T(8;14) is _______, which means overexpression of ________ and its function is _______
    • Burkitt lymphoma
    • c-Myc
    • promotes cell growth
  14. Translocation mutations for: Burkitt, mantle cell, follicular lymphomas
    • Burkitt- t(8;14)
    • Mantle cell- t(11;14)
    • Follicular – t(14;18)
  15. Jaw mass seen in African child, think:
    Burkitt Lymphoma
  16. Which lymphoma shows “starry-sky” on microscopy?
    Burkitt lymphoma
  17. T/F: African/Endemic form of Burkitt lymphoma is the most common
    False; most common form of Burkitt is sporadic, which is rarely EBV+ and does not usually have jaw involvement like in African/Endemic form.
  18. What are the aggressive NHL:
    • Mantle Cell lymphoma
    • Diffuse large B cell lymphoma
    • Burkitt lymphomaa
Card Set
Lymphoma Genetics
HemeOnc Midterm 2