Cancers that develop from lymphocytes, forms a mass in the lymph nodes
What is most common cell type involved in lymphomas?
B cells
T/F: Hodgkins lymphomas are the most common type of lymphoma, accounting for 90% of all lymphomas
False; it is non-hodgkins lymphoma that is the most common
EBV is often involved in which non-hodgkin lymphoma(s)?
Burkitt lymphoma
10-15% cases of Diffuse Large B cell lymphoma
Burkitt and follicular lymphoma arise from ______. Mantle cell lymphoma arises from ______. Diffuse large B cell lymphoma arises from_______. And multiple myeloma (not a lymphoma) arises from______.
Germinal center B cells
Naïve mature B cells (one step before germinal center reaction)
Plasmablast
Plasma cell
Which of the non-hodgkin lymphoma is the most common one?
Diffuse large B cell lymphoma
These are aggressive but potentially curable
Which NHL can develop in extranodal sites?
Diffuse large B cell lymphoma
Burkitt lymphoma (in child especially)
T/F: NHL B cells all express CD 15 and CD 30
False; B cells are CD20 +; CD15+ and CD30+ is classically for hodgkins lymphoma
What are the Heavy Chain NHL? What does Heavy chain mean?
Burkitt
Follicular
Mantle Cell
Heavy chain – IGH (immunoglobulin heavy chain) on Chromosome 14 is strong and leads to higher transcription levels, so with translocation of genes to this site it generates oncogene proliferation
Proliferations of Cyclin-D1 is _________, c-Myc is ________ and BCL-2 is _______
Mantle cell lymphoma (clyclinD1)
Burkitt lymphoma (c-Myc)
Follicular lymphoma (BCL2)
T(14;18) is ______, which means overexpression of _________ and its function is ________
Follicular lymphoma
BCL2
To stop apoptosis.
T(11;14) is _______, which means overexpression of_______ and its function is ________
Mantle cell lymphoma
CyclinD1
Promote G1/S transition in the cell cycle facilitating neoplastic proliferation
T(8;14) is _______, which means overexpression of ________ and its function is _______
