Thalassemia Genetics

Most prevalent adult hemoglobin has these globin subunits:

The alternative form of adult hemoglobin has these globin subunits:

Fetal hemoglobin has _____ affinity for oxygen due to its ____ subunit

Homotetramer of _____, Hb____, is observed with alpha-thalassemia

Alpha thalassemia observed in fetus is also known as ___

Alpha globin at chromosome ___ and non-alpha globin at chromosome ____

T/F: fetal hemoglobin is present right at start of gestational period (day 0)
True False

Embryonic hemoglobin:

Epsilon globin _____ at the same rate as _____ globin increases, which then decreases at the same rate that ___ globin increases and is supplemented by _____ globin

Deficiency of which globin is fatal to early embryonic stage:

T/F: deficiency of delta globin is usually fatal
True False

T/F: beta thalassemia is irrelevant prior to birth
True False

Beta globin deficiency can cause insufficiency of ______ (hemoglobin tetramer), as well as an excess of ____ globin subunit

What happens with excess alpha globin in beta-thalassemia?

Betal thalassemia minor vs beta thalassemia major:

What is Cooley anemia?

What is beta thalassemia intermedia?

HbH and Hb Barts oxygen binding ability:

African pattern of alpha thalassemias vs Asian pattern of alpha thalassemia (alpha thal minor)

HgH disease is alpha thalassemia _____

Hydrops fetalis is _____

Only one alpha globin is deleted, this is: