-
White cell disorder scheme, 1st branch point:
Quantitative vs qualitative
-
What does qualitative entail?
- Abnormal appearing cells due to either extrinsic or intrinsic changes
- Extrinsic: chemotherapy, corticosteroids
- Intrinsic: defect in component of the cell, lysosome, cytoplasm
-
A hypolobulated neutrophil is indicative of (qualitative/ quantitative) white blood disorder
Qualitative
-
Next branch under Quantitative is?
Leukocytosis vs leukopenia
-
Leukopenia is described as wbc count below _____
4000
-
T/F: leukopenia is almost always identified as neutropenia
True
-
Branching off leukopenia is ____ vs _____
Malignant vs non malignant
-
Benign causes of leukopenia:
- Autoimmune
- Malnutrition
- Some drugs
-
Malignant causes of leukopenia:
- Chemotherapy induced bone marrow suppression
- Radiation treatments
- Cancers like lymphoma, myelodysplasia, multiple myeloma, hairy cell leukemia, metazoic solid tumors
-
Brach points off of neutrophilia (causes of neutrohilia)?
- Infection
- Stress states (like exercise, stress, epinephrine)
- Malignancy (like chronic myeloid leukemia, large cell lung cancer)
- Pharmacologic (like glucocorticoids, lithium)
-
Non-malignant lymphocytosis:
- Asthma
- Seasonal allergy
- EBV
-
Malignant lymphocytosis:
- Acute lymphoblastic leukemia
- Chronic lymphocytic leukemia
-
Atopic dermatitis causes ______
Eosinophilia
-
Eosinophilia infection is usually due to ___ and ___
Worms and fungal
-
Chronic myeloid leukemia could cause ____, ____ and/ or ____
- Neutrophilia
- Eosinophilia
- Basophilia
-
Malignant eosinophilia:
Leukemia, solid tumors
-
Acute lymphocytic leukemia causes ____ and/or ____
- Lymphocytosis
- Blast cells (almost always indicative of ALL)
-
Blast cell is almost always indicative of ____
Acute lymphocytic leukemia
-
Blast cells are immature precursors of:
-
Monocytosis is increased in:
Precursors to macrophages
-
______ creates inflammatory mediators ie histamine and heparin
Basophilia
-
Varicella leads to ____
Basophilia
-
T/F: basophilia attracts leukocytes to infections
True
-
Hodgkins disease causes ___ and ____
-
Specific granules in basophils:
- Proteoglycans
- Histamine a
- Neutral proteases
|
|
