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pharma 3

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  1. Non-classical angina pectoris:
    Variant/prinzmetal angina.

    Aim dilates bvd(CCB blockers used bt dipines contraindicated).
  2. Most potent vasodilator is:
    Iachemia.
  3. To decrease workload in angina pectoris,drugs used are:
    • Nitrates.
    • CCB.
    • Beta blockers.
  4. Minimum first pass metabolism in:
    Isosorbide mononitrate.

    • Pent erythrital tetranitate(PETN):
    • Longest acting.

    • Amyl nitrite:
    • Shortest acting.
    • Dynamite factory.
    • Nitrate tolerance.
    • Monday dzs.
  5. Nitrates is contraindicated with:
    • PDE inhibitors like sildenafil.
    • Bcz severe vasodilation present.
  6. Why dipines are contraindicated in angina pectoris:
    Reflex tachycardia and workload is increased.
  7. Beta blockers used in which angina types?
    Classical angina.
  8. Metabolism modulators are:
    • Ranolazine.
    • Trimetazidine.

    • Major adv:
    • Do not cause hypotension.
  9. Bradycardia agent:
    • Ivabradine.
    • (Funny current).
  10. Coronary steal phenomenon by:
    • Hydralazine.
    • Isoflurane.
    • Dipyridamole.
  11. RHOKINASE blockers:
    Fasudil.
  12. MI management in STEMI N-STEMI:
    • STEMI: @SONA.
    • streptokinase.
    • O2.
    • Nitrates.
    • Aspirin.


    • N-stemi:@MONA
    • morphine.
    • O2.
    • Nitrates.
    • Aspirin.
  13. Barbiturates
    • GABA mimetics.
    • Increase duration of CL-channel opening.
    • Enzyme inducer.

    • BZDS:
    • GABA facilatory.
    • Increase frequency of chloride channels.
    • No enzyme induction.
  14. Disadvantages of diazepam:
    -Hangover d/t longer duration of action d/t active metabolite.

    -Should be avoided in elderly n hepatic failure.
  15. Shorter acting BZDS:
    • @STOLE.
    • Tomazepam.
    • Oxazepam.
    • Lorazepam.
    • Estazepam.
  16. Barbiturates n Benzodiazepines act in which phase of NREM:
    Phase-2.

    Dream is present in REM phase.
  17. Z-drugs are:
    • Zolpidem.
    • Zaleplon.
    • Zopiclone.

    DOC for:insomnia.
  18. Ramelton is
    • Receptor agonist melatonin.
    • Used for:
    • -jet lag phenomenon.
    • Shift workers.
  19. Parkinsonism is d/t:
    • Deceased dopamine.
    • Increased ACH.
  20. Dopamine precursor:
    Levodopa.

    Release enhancer:amantadine.
  21. MAO-A,MOA-B inhibitors:
    • MOA-A:
    • ADR.
    • NOR AD.
    • DOPAMINE.
    • 5HT(SEROTONIN).

    MOA-B:

    • SELEGILINE.
    • RASAGILINE.
  22. COMT-INHIBITORS:
    • Entacapone.
    • Tolcapone.
  23. Dopamine receptor agonist:
    • Ergot derivatives:
    • Bromocriptine.
    • Pergolide.

    • Non-ergot:
    • Pramipexole.
    • Ropinirole.
  24. DOC for diabetic neuropathy n post herpetic neuralgia:
    Pregabalin.
  25. Infantile spasm/west syndrome/salam seizure:
    ACTH.

    Infantile spasm a/w tuberous sclerosis:vigabatrin.
  26. Epilepsy defn:
    Tendency to have seizures/convulsions.
  27. Antiepileptics t/t approach:
    • Increase GABA:increase inhibitory neurotransmitters.
    • Decrease glutamate:decrease excitatory neurotransmitters.

    • Sodium channel blockers.
    • Ca channel blockers.(T-types).
  28. Na+ channel blockers:
    • Topiramate:S/E wt loss,renal stones.
    • Zonisamide:renal stones.
  29. Phenytoin S/E:
    @HOT MALIKA

    • Hirsutism.
    • Oestomalacia:Rx=give vit D.
    • Teratogenic(fetal hydantoin syndrome).
    • Megaloblastic anemia.(decreased folate absorption).
    • Arrhythmia.
    • Lymphadenopathy(pseudolymphoma).
    • Inhibit insulin release(C/I:DM).
    • Vit k supplementation in a mother.
    • Ataxia,nystagmus,vertigo.
  30. Lamotrigine major S/E:
    SJS.
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Author
Sachinchaudhary
ID
348027
Card Set
pharma 3
Description
pharma 3
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