pharma

  1. Important enzyme inducers:
    • @GPRS CELL PHONE.
    • Griseofulvin.
    • Phenobarbinote.
    • Rifampicin.
    • Smoking.
    • Carbamazepine,chronic alchohol
    • Phenytoin.
  2. Imp enzymes inhibitors:
    • @vit k can cause enzyme inhibition and some molecules omit.
    • Valproate.
    • Ketoconazole.
    • Cemitidine.
    • Ciprofloxacin.
    • Erythromycin.
    • INH.
    • Acute alcohol,grape juice.
    • Sulfonamides.
    • Metronidazole.
    • Omeprazole.
  3. Unionized form.
    Ionized form.
    • Lipid soluble,crosses the membrane.
    • Water soluble,doesn't.
  4. Bioavailability:
    (AUC)oral/(AUC)IV *100
  5. Why preferred route is sublingual in nitroglycerin.
    • Immediate action.
    • By pass 1st pass metabolism.
    • Self-administration is possible.
    • Extradose can be controlled.
  6. Excepients:
    Substances added to the active drug to make it more stable.
  7. Presence of barriers:
    • Posterior pituitary.
    • Area prostema.
    • Lamina termales
    • Organum vasculosum.
  8. Volume of distribution:
    • @VDC.
    • Amount of drug given(dose)/plasma concentration(concn).

    • Loading dose:Vd * target plasma conc.
    • Maintenance dose:clearance*target plasma conc.
  9. Phase 1 metabolic rxns.(catabolic)
    Phase 2 metabolic rxns.(anabolic or conjugation)
    • Oxidation.
    • Reduction.
    • Hydrolysis.
    • Cyclization.
    • Deamination.
    • Aim:to make drug sticky.

    • Glucoronide.
    • Glutathione.
    • Acyl.
    • Methyl.
    • Sulfate.
    • Glycine.
    • Aim:to attach functional group to the drug.
Author
Sachinchaudhary
ID
348021
Card Set
pharma
Description
pharma
Updated