pharma 2 mudit.

  1. Phosphodiesterase inhibitors
    • Dipyridamole.
    • Cilostazol.
  2. Atypical antipsychotic to induce hyperprolactinoma:
    • High:risperidone
    • Little:olanzapine,ziprasidone.
    • No:clozapine
  3. Drug targeting both HBV n HIV:
    Tenofovir

    • Lamivudine.
    • Emtricitabine.
  4. Anti CD25 drugs:
    • Basiliximab.
    • Daclizumab.


    • Anti CD20:Rituximab.
    • Anti CD3:Muromonab.
    • Anti CD52:Alemtuzumab.
  5. Drugs not requiring lab coagulant profile monitoring:
    Dabigatran.(direct factor xa inhibitor).

    Heparin,warfarin,argatroban require close monitoring.
  6. Antihypertensive drugs in pregnancy:
    • First line agents:methyl dopa,labetolol.
    • Second line:hydralazine,nifedipine,clonidine.
    • Avoided:atenolol,diuretics,nitroprusside.
  7. Testing of HLA-B57 is needed for:
    Abacavir.
  8. Thrombin receptor antagonist:
    Vorapaxar.
  9. D-tubocurarine is:
    Competitive,non-depolarizing block at Nm cholinergic receptors.
  10. Neprilysin inhibitor:
    Sacubitril.
  11. Aldosterone secretion is stimulated by:
    • Hyperkalemia.
    • Angiotensin-2,3
    • ACTH.
    • Vasopressin,endothelin,sertonin.


    • Inhibitory:
    • ANP
    • Somatostatin
    • Dopamine
  12. MOA of fluconazole.
    Inhibits lanosterol 14-demethylase.


    Allylamines inhibits squalene apoxidase n blocks biosynthesis of ergosterol.

    Flucytosine interferes with DNA n RNA synthesis.

    Griseofulvin causes disruption of mitotic spindle n inhibition of fungal mitosis.
  13. Serious interaction with tadalafil occurs with:
    Nitrates.

    Causes potentially fatal hypotension.

    Nitric oxide pathway:cGMP.
  14. Glucocorticoid synthesis inhibitor:
    • Metyrapone.
    • Etomidate.
    • Ketoconazole.
  15. Fifth generation cephalosporin active against MRSA:
    Ceftaroline.

    • Other 5th generation:
    • Anti-pseudomonal:ceftolozane.
    • Anti-pseudomonal n Anti-MRSA:ceftobirole.
  16. JAK inhibitors:
    Tofacitinib.

    • TNF inhibitors:
    • Eternacept.
    • Infliximab.
    • Adalimumab.
    • Golimumab.
    • Certolizumab.
  17. Topical steroids high potency drugs include:
    Class 2 n 3.(eg. Betamethasone).

    Ultrahigh:class 1.(clobetasol).

    Moderate:class 4,5(hydrocortisone valerate).

    Low:6,7(desonide-class 6,hydrocortisone acetate-7).
  18. MOA of aprepitant:
    NK1 antagonist.(chemotherapy induced nausea n vomiting).

    • Ondansetron,granisetron:5-HT3 antagonist.
    • (Chemotherapy n radiation induced emesis.
    • Postoperative emesis).

    Others antiemetic:

    Neuroleptics:chlorpromazine,prochlorperazine.
  19. Antihistamines classification:
    • Highly sedative:
    • Diphenhydramine,dimenhydrinate.

    • Moderately sedative:
    • Pheniramine,promethazine.

    • Mild sedative:
    • Chlorpheniramine,Triprolidine.

    • Second generation(least sedative).
    • Fexofenadine.
    • Loratadine.
    • Cetrizine.
    • Levocetrizine.
    • Ebastine.
  20. SERM:
    SERD:
    LHRH agonists:
    EXAMPLES are
    • Tamoxifen.
    • Fulvestrant.
    • Goserelin,Triptorelin.
  21. Antimalarials most effective in reducing p.falciparum:
    Primaquine.(among the options primaquine,quinine, chloroquine,Artemisinin,)
  22. Denosumab used in t/t of:
    Osteoporosis.

    It is an antibody that blocks RANKL ligand and dramatically reduces osteoclast number n function.
  23. Highly ionized drug is:
    Excreted mainly by kidney.

    • are lipid insoluble.
    • Poorly absorbed from stomach n intestine.
    • Poorly pass across placenta.
    • They are not reabsorbed by tubules n hence easily excreted.
  24. Enzyme inhibited by aminophylline:
    Phosphodiesterase.
  25. Phenytoin is a/w hperglycemia or hypoglycemia?
    Hyperglycemia.
  26. Topically used sulphonamides:
    • Silver sulfadiazine.
    • Sulfacetamide.
    • Mafenide.
  27. True abt orphan drugs:
    Includes drugs for some common dzs in developing countries.
  28. Logarithmic graded dose response curve is:
    Sigmoid.


    • Airthmetic graded dose response curve is:
    • Rectangular hyperbola.
  29. Agoinst-antagonist:
    Alpha 1
    Alpha 2
    Beta 1
    Beta 2
    • Phenylephrine-prazosin @(PP).
    • Clonidine-yohimbine@(CY)

    • Dobutamine-Atenolol@ (DAS.bahadur).
    • Salbutamol-butoxamine.
  30. What is the effect of adrenaline when administered after alpha-receptors blockade:
    Fall in blood pressure.
  31. MOA of levosimenden:
    Calcium sensitizer.


    • Omecamtiv mecarbil:selective myosin activator.
    • Istaroxmine:Na+/K+ - ATPase inhibitor.
  32. Cholesteryl ester transfer protein(CTEP) inhibitor for t/t of dyslipidemia:
    Torcetrapib.

    • MTP inhibitors:lomitapide.
    • PCSK9 inhibitors:evolocumab,alirocumab.

    • Antisense inhibition of Apo B-100 synthesis:
    • Mipomersen.
  33. First line drugs for t/t of HTN.
    • Thiazide diuretics.
    • ACE inhibitors.
    • CCB.

    Beta-blockers not included.
  34. Thiazide when combined with which drug becomes inffective:
    Calcium channel blockers.
  35. Pill induced esophagitis is a/w:
    Doxycycline.
  36. Carbapenems not recommended for treatment of nosocomial infxns:
    Ertapenem.

    • Used are:
    • Imipenem.
    • Meropenem.
    • Doripenem.
  37. Ertapenem is not effective against:
    Pseudomonas.
  38. Gramicidin S is:
    Cyclic decapeptide.
  39. Following ATT has highest sterilization action:
    Rifampicin.
  40. Following ATT has highest ability to prevent emergence of resistance to isoniazid:
    Rifampicin.
  41. T/t of choice of TB in pregnancy:
    HRE 2 months, and HR 7 months.
  42. Can oseltamivir be co-adminstered with vaccine.
    No.

    It is neuraminidase inhibitor.
Author
Sachinchaudhary
ID
348020
Card Set
pharma 2 mudit.
Description
pharma
Updated