-
Most potent cerebral vasodilator.
- Nimodipine.(cerebroselective CCB of the dihydropyridine).
- Then nifidipine.
- Verapamil.
- Diltiazem.
-
Thiazide diuretics used in:
- HTN.
- heart failure.
- Nephrolithiasis from idiopathic hypercalciuria.
-
Drug a/w increased risk of drug induced urinary calculi:
- Furosemide.
- Acetazolamide.
- Triamterene.
- But thiazide decrease the urinary calcium.
-
Pt with idiopathic hypercalciuria has renal calculi,drug contraindicated is:
Furosemide.
Drugs which can be used are thiazide,spironolactone,amiloride.
-
Drugs causing sinus tachycardia.
Theophylline,atropine,nifidipine.
Sinus bradycardia:clonidine.
-
Apixaban is:
Factor xa inhibitor.
- Indirect xa inhibitor:fondaparinux,idraparinux.
- Oral direct thrombin inhibitor:dabigatran.
- Parental direct thrombin inhibitors:hiruden,argatroban.
-
Clopidogrel is a substrate for
CYP2 C19.
While PPIS are substrate and inhibitors for CYP2 C19.
-
Hypolipidemic drugs a/w vit b12 deficiency:
Metformin.
-
Drug with low therapeutic index.
Lithium.
Hit n run drugs:resperine,Guanethidine,MAO inhibitors,omeprazole.
-
Drugs on overdose causing features of cyanide toxicity:
- Sodium nitroprusside.
- Toxicity:>5 microgm/kg/min.
-
Serotonin dopamine antagonist are:
- Risperidone.
- Sertindole.
- Zotepine.
- D2-D3 antagonists:amisulpride,remoxipride.
- Partial dopamine receptor agonist:arpiprazole.
-
About clozapine:
- Lower potency to block D2 receptors.
- Clozapine discontinued:wbc <350 ng/ml.
- Blood clozapine levels maintained >350 ng/ml to prevent risk of agranulocytosis.
-
Ergotamine ADR:
- Nausea.
- Vomiting.
- Tingling.
- Numbness n bluish discoloration.
-
Mast cell stabilizers MOA:
Inhibit mast cell degranulation n release allergic mediators by preventing ca influx across mast cell membranes.
-
Bactericidal drugs:
Isoniazid,moxifloxacin,daptomycin.
Tigecycline(like tetracylines) are bacteriostatic.
- BACTERIOSTATIC DRUGS:@(kc does LT ST).
- chloramphenicol.
- Ketolides.
- Linezolid.
- Tetracyclines,tigecycline.
- Sulfonamides.
- Trimethoprim.
- Bacteriostatic n bactericidal drugs:@(CMS)
- Clindamycin.
- Mupirocin.
- Streptogramins.
- Erythromycin n other macrolides.
-
Cell wall syntesis inhibitor.
Protein synthesis inhibitor.
Nucleic acid synthesis inhibitor.
Destruction of DNA.
Disruption of cell membranes.
Enzyme activity inhibitor.
- Penicillin,Cephalosporins,daptomycin,vancomycin,carbapenem.
- Aminoglycosides,tetracycline,macrolides,mupirocin,streptogramins.
- Quinolones,rifampin.
- Metronidazole.
- Polymixin B,polymixin E.
- Sulfonamides,trimethoprim.
-
Effective drugs for MRSA:
- Vancomycin.
- Ciprofloxacin.
- Cotrimaxazole.
-
Fluroquinolones with longest half life:
- Sparfloxacin.
- Moxifloxacin.
- Lomefloxacin.
- Fluoroquinolones not requiring renal dose adjustment:
- Trovafloxacin.
- Moxifloxacin.
-
Antiretroviral drugs Ritonavir S/E:
- Lipodystrophy
- Hypertriglyceredemia.
- Hypercholesterolemia.
-
Adr of Thalidomide:
- Constipation.
- Sedation,fatigue.
- Peripheral neuropathy.
-
Drug used in cryptosporidiasis.
Nitrazoxamide which inhibit pyruvate Ferrodoxomine oxidoreductase.
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