-
Most common malignancy of bone.
Most common primary malignant bone tumor.
M/c true malignant bone tumor.
M/c benign bone tumor.
M/c true benign bone tumor.
- Secondaries(breast,prostate,kidney).
- Multiple myeloma.
- Osteosarcoma.
- Osteochondroma.
- Osteoid osteoma.
-
Epiphysis.
Metaphysis.
Diaphysis.
- Osteoclastoma(adult).
- Chondroblastoma.
- Osteoclastoma.(children).
- Osteosarcoma.
- Osteoblastoma.
- Osteochondroma.
- Unicameral bone cyst(simple bone cyst).
- Aneurysmal bone cyst.
- Chondrosarcoma.
- Ewing sarcoma.
- Osteiod osteoma.
- Multiple myeloma.
- (Also fibrous dysplasia,adamantinoma,lymphoma)
-
Osteolytic bone tumor.
Osteoblastic bone tumor.
- Kidney,thyroid,lung,GIT
- Prostate,breast,testis.
-
Osteosarcoma
- 10-25 yrs.
- Metaphysis.
- Distal femur.
- Mutation pRB n p53 protein.
- A/w retinoblastoma,pagets dzs.
- Increased osteiod formation by neoplastic cells.
- Hair end appearance.
- Bone marrow biopsy nt indicated.
- Chemo-limb salvage surgery-chemo.
-
Small round blue cell tumor.
@MR2 LEEP.
- medulloblastoma.
- Rhabdomyosarcoma.
- Retinoblastoma.
- Lymphoma.
- Esthesioneuroblastoma.
- Ewing sarcoma.
- PNET(peripheral neuroectodermal tumor)
-
Radiosensitive tumor.
@We SMyle
- Wilms tumor.
- Ewings sarcoma.
- Seminoma.
- Myeloma.
- Lymphoma.
-
Radioresistant tumor.
@ M-HOPe
- Melanoma.
- Hepatoma.
- Osteosarcoma.
- Pancreatic ca.
-
Ewing's sarcoma.
- Endothelial sarcoma.
- Translocation.(11:22).
- 20-40 yrs.
- Diaphysis.
- Lytic lesion.
- Onion peel appearance.
- Small round blue positive,intracellular glycogen deposit.
- Mic-2 gene,CD99 +ve.
- Confused with osteomyelitis.
- T/t:Radiation +CT f/b excision.
-
Chondroblastoma.
- 5-25 yrs.
- Epiphysis.
- Cartilaginious tumor.
- Humerus,sclerotic border with scattered calcification.
-
Chondrosarcoma.
- Cartilagenous tumor.
- From chondrocyte.
- Pelvis.
- Mottled calcification and endosteal scalloping.
-
Chordoma.
- From notochord remnants.
- Locally malignant tumor.
- Sacrum.
- Ribs unlikely.
-
Adamantinoma.
- Ameloblastoma.
- Posterior mandible.
- Honey comb.loculated lesion.
- T/t:wide local excision.
-
Mandible
Pelvis
Sacrum
Distal femur
Tibia
Tibia+vertebrae
Upper end of humerus
Shaft of femur
Frontal bone.
- Adamantinoma.
- Chondrosarcoma.
- Chordoma.
- Osteosarcoma,osteoclastoma.
- Osteiod osteoma.
- ABC.
- Simple bone cyst(unicameral bone cyst),chondroblastoma.
- Ewing sarcoma.
- Potts puffy tumor.
-
Osteoclastoma
- 》15 giant cell nuclei.
- 20-40yrs.
- Epiphysis.
- Distal femur then proximal tibia.
- Soap bubble appearance.
- Excision.
-
Osteochondroma.
- Benign tumor.
- M/c site:cartilagenous end of femur or tibia.
-
Osteiod osteoma.
- Benign tumor.
- 5-25 yrs.
- Diaphysis.
- Tibia common.
- Central nidus<1.5 cm.
- X-ray:lytic lesion surrounded by zone of sclerosis.
-
Chondroma.
- Hyaline cartilage.
- Enchondroma,Ecchondroma.
- Maffuci syndrome(enchondroma with hemangioma).
- Ollier syndrome(multiple enchondromas,polyostotic in nature)
-
Simple bone cyst(unicameral bone cyst)
- <20 yrs.
- Upper end/proximal end of humerus.
- Metaphysis.
- Asymtomatic,pathological #.
- Cystic lesion,lytic
-
Aneurysmal bone cyst.
- 10-40 yrs.
- X ray:expansive lytic lesion in transverse processs of vertebrae.
-
Osteosarcoma.
Osteiod osteoma.
Adamantinoma.
- Increased osteiod formation by neoplastic cells.
- Lucent nidus<1.5 cm.
- Islands of epithelial cells in a fibrous stroma.
-
X-ray findings:
Simple bone cyst.
Aneurysmal bone cyst.
Osteiod osteoma.
Chondroblastoma.
Chondrosarcoma.
- Cystic central lytic lesion in proximal end of humerus.
- Expansive lytic lesion in transverse process of vertebrae n tibia
- Lytic lesion surrounded by zone of sclerosis.
- Sclerotic border with scattered calcification.
- Mottled/patchy calcification with endosteal scalloping.
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