Bone tumors

  1. Most common malignancy of bone.
    Most common primary malignant bone tumor.
    M/c true malignant bone tumor.
    M/c benign bone tumor.
    M/c true benign bone tumor.
    • Secondaries(breast,prostate,kidney).
    • Multiple myeloma.
    • Osteosarcoma.
    • Osteochondroma.
    • Osteoid osteoma.
  2. Epiphysis.

    Metaphysis.

    Diaphysis.
    • Osteoclastoma(adult).
    • Chondroblastoma.


    • Osteoclastoma.(children).
    • Osteosarcoma.
    • Osteoblastoma.
    • Osteochondroma.
    • Unicameral bone cyst(simple bone cyst).
    • Aneurysmal bone cyst.
    • Chondrosarcoma.



    • Ewing sarcoma.
    • Osteiod osteoma.
    • Multiple myeloma.
    • (Also fibrous dysplasia,adamantinoma,lymphoma)
  3. Osteolytic bone tumor.
    Osteoblastic bone tumor.
    • Kidney,thyroid,lung,GIT
    • Prostate,breast,testis.
  4. Osteosarcoma
    • 10-25 yrs.
    • Metaphysis.
    • Distal femur.
    • Mutation pRB n p53 protein.
    • A/w retinoblastoma,pagets dzs.
    • Increased osteiod formation by neoplastic cells.
    • Hair end appearance.
    • Bone marrow biopsy nt indicated.
    • Chemo-limb salvage surgery-chemo.
  5. Small round blue cell tumor.
    @MR2 LEEP.

    • medulloblastoma.
    • Rhabdomyosarcoma.
    • Retinoblastoma.
    • Lymphoma.

    • Esthesioneuroblastoma.
    • Ewing sarcoma.
    • PNET(peripheral neuroectodermal tumor)
  6. Radiosensitive tumor.
    @We SMyle

    • Wilms tumor.
    • Ewings sarcoma.
    • Seminoma.
    • Myeloma.
    • Lymphoma.
  7. Radioresistant tumor.
    @ M-HOPe

    • Melanoma.
    • Hepatoma.
    • Osteosarcoma.
    • Pancreatic ca.
  8. Ewing's sarcoma.
    • Endothelial sarcoma.
    • Translocation.(11:22).
    • 20-40 yrs.
    • Diaphysis.
    • Lytic lesion.
    • Onion peel appearance.
    • Small round blue positive,intracellular glycogen deposit.
    • Mic-2 gene,CD99 +ve.
    • Confused with osteomyelitis.
    • T/t:Radiation +CT f/b excision.
  9. Chondroblastoma.
    • 5-25 yrs.
    • Epiphysis.
    • Cartilaginious tumor.
    • Humerus,sclerotic border with scattered calcification.
  10. Chondrosarcoma.
    • Cartilagenous tumor.
    • From chondrocyte.
    • Pelvis.
    • Mottled calcification and endosteal scalloping.
  11. Chordoma.
    • From notochord remnants.
    • Locally malignant tumor.
    • Sacrum.
    • Ribs unlikely.
  12. Adamantinoma.
    • Ameloblastoma.
    • Posterior mandible.
    • Honey comb.loculated lesion.
    • T/t:wide local excision.
  13. Mandible
    Pelvis
    Sacrum
    Distal femur
    Tibia
    Tibia+vertebrae
    Upper end of humerus
    Shaft of femur
    Frontal bone.
    • Adamantinoma.
    • Chondrosarcoma.
    • Chordoma.
    • Osteosarcoma,osteoclastoma.
    • Osteiod osteoma.
    • ABC.
    • Simple bone cyst(unicameral bone cyst),chondroblastoma.
    • Ewing sarcoma.
    • Potts puffy tumor.
  14. Osteoclastoma
    • „Äč15 giant cell nuclei.
    • 20-40yrs.
    • Epiphysis.
    • Distal femur then proximal tibia.
    • Soap bubble appearance.
    • Excision.
  15. Osteochondroma.
    • Benign tumor.
    • M/c site:cartilagenous end of femur or tibia.
  16. Osteiod osteoma.
    • Benign tumor.
    • 5-25 yrs.
    • Diaphysis.
    • Tibia common.
    • Central nidus<1.5 cm.
    • X-ray:lytic lesion surrounded by zone of sclerosis.
  17. Chondroma.
    • Hyaline cartilage.
    • Enchondroma,Ecchondroma.
    • Maffuci syndrome(enchondroma with hemangioma).
    • Ollier syndrome(multiple enchondromas,polyostotic in nature)
  18. Simple bone cyst(unicameral bone cyst)
    • <20 yrs.
    • Upper end/proximal end of humerus.
    • Metaphysis.
    • Asymtomatic,pathological #.
    • Cystic lesion,lytic
  19. Aneurysmal bone cyst.
    • 10-40 yrs.
    • X ray:expansive lytic lesion in transverse processs of vertebrae.
  20. Osteosarcoma.
    Osteiod osteoma.
    Adamantinoma.
    • Increased osteiod formation by neoplastic cells.
    • Lucent nidus<1.5 cm.
    • Islands of epithelial cells in a fibrous stroma.
  21. X-ray findings:
    Simple bone cyst.
    Aneurysmal bone cyst.
    Osteiod osteoma.
    Chondroblastoma.
    Chondrosarcoma.
    • Cystic central lytic lesion in proximal end of humerus.
    • Expansive lytic lesion in transverse process of vertebrae n tibia
    • Lytic lesion surrounded by zone of sclerosis.
    • Sclerotic border with scattered calcification.
    • Mottled/patchy calcification with endosteal scalloping.
Author
Sachinchaudhary
ID
348015
Card Set
Bone tumors
Description
ortho
Updated