Pulmonary Pharmacology Lecture 2

  1. Who does asthma typically affect?
    • Women
    • Kids
    • African Americans
    • Living in the N. East
    • Below poverty level
    • Work Exposure (asbestos, fine particulates)
  2. How is asthma characterized?
    Activation of mast cells, infiltrates of eosinophils, T helper 2
  3. Asthma is considered a "reversible" disease, whereas COPD is considered to be a ____ disease.
  4. Name common triggers of asthma
    • Pollen
    • Smoke
    • Mold
    • Pollution
    • Exercise
    • Perfumes
    • Pet Dander and dust mites
  5. When is the onset of asthma typically?
    Early in life
  6. COPD is characterized physiologically by ___.
    the predominance of neutrophils, macrophages, and cytotoxic T 1 cells
  7. How does COPD affect the lungs?
    inflammation affects small airways resulting in progressive small airway narrowing and fibrosis
  8. Changes in the airways in people with COPD results in ___.
    airway closure on expiration leading to air trapping and hyperinflation
  9. What are common causes of COPD?
    • Smoking
    • Environmental factors
  10. When is the onset of COPD?
  11. What do COPD and asthma have in common?
    chronic inflammation of the airways
  12. What can help keep patients out of acute exacerbations?
    Routine maintenance medications
  13. COPD patients often have ____ PaO2 and ____PaCO2 levels.
    lower; higher
  14. What is the preferred route of medication delivery for COPD and asthma patients?
    Oral route
  15. β2 receptors cause ____ of smooth muscle in the lungs.
  16. Which system affects the lung airways in a slow action mechanism, sympathetic or parasympathetic system?
    parasympathetic system
  17. What are β2 Adrenergic Agonists used for?
    Bronchodilator for COPD or Asthma
  18. Name short acting beta agonists
  19. What are the 3 subcategories of bronchodilators used to treat Asthma?
    • Beta agonists
    • Muscarinic antagonists
    • Methylxanthines
  20. What are the  3 main drug categories used to treat Asthma?
    • Bronchodilators
    • Anti-inflammatory agents
    • Leukotriene antagonists
  21. What are the 4 anti-inflammatory agents used to treat asthma?
    • Release inhibitors
    • Steroids
    • Antibodies
    • Allow anti-inflammatory drugs
  22. What are the 2 categories of leukotrienes antagonists to treat asthma?
    • Lipoxygenase inhibitors
    • Receptor inhibitor
  23. What are the main drug categories used to treat COPD?
    • Bronchodilators
    • Anti-inflammatory agents (steroids)
    • Antibiotics
Card Set
Pulmonary Pharmacology Lecture 2
Pulmonary pharmacology and treatment