Pharmacology

  1. -prazole
    proton pump inhibitor
  2. -stat
    lipid lowering agent
  3. -lukast
    Leukotriene receptor antagonist
  4. -oxetine
    selective serotonin re-uptake inhibitor
  5. -sartan
    angiotensin II receptor antagonist
  6. -oxacin
    fluoroquinolone antibiotics
  7. -vir
    antiviral compounds
  8. -mab
    monoclonal antibodies
  9. -afil
    phosphodiesterase 5 inhibitors
  10. -olol
    beta blocking agents
  11. -pril
    angiotensin converting enzyme inhibitors
  12. Generic name: Atrovastatin
    Brand name: Lipitor

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  13. Generic name: Lansoprazole
    • Brand name: Prevacid
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  14. Generic: Montelukast
    • Brand name: Singulair
    • singulair-chewable-tab-5-mg-asthma-28-tablets
  15. Generic name: Fluoxetine
    • Brand name: Prozac
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  16. Generic name: Valsartan
    Brand name: Diovan

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  17. Generic name: Levofloxacin
    Brand name: Levaquin

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  18. Generic name: Acyclovir
    Brand name: Zovirax61A-huIWAaL._SX466_
  19. Generic name: Bevacizumab
    Brand name: Avastinavastin-300x230
  20. Generic name: Sildenafil
    Brand name: Viagra

    cheap-viagra-100-mg-for-men-300x231
  21. Generic name: Metoprolol
    Brand name: Tenormin

    3ac357b6f649de3c5cc5a8c84c65c52279a24ae0
  22. Generic name: Enalapril
    Brand name: Vasotec

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  23. Atorvastin (Lipitor)
    (- stat ) Lipid lowering agent
  24. Lansoprazole (Prevacid)
    (-prazole) Proton Pump Inhibitors
  25. Montelukast (Singulair)
    (- lukast)  Leukotriene receptor antagonist
  26. Fluoxetine (Prozac)
    ( -oxetine) Selective Seretonin Reuptake Inhibitor
  27. Valsartan (Diovan)
    ( -sartan) Angiotensin II Receptor Antagonist
  28. Levofloxacin (Levaquin)
    (- oxacin) Fluoroquinolone Antibiotics
  29. Acyclovir (Zovirax)
    ( -vir) Antiviral compounds
  30. Bevacizumab (Avastin)
    (-mab) Monoclonal Antibodies
  31. Sildenafil (Viagra)
    (-afil) Phosphodiesterase 5 inhibitors
  32. Metoprolol (Tenormin)
    ( -olol) Beta Blocking Agents
  33. Enalapril (Vasotec)
    ( -pril) Angiotensin Converting Enzyme Inhibitors
  34. Pure food and drug act of 1906
    Established the food and drug administration

    It required people to start labeling products.
  35. Food Drug and Cosmetic Act of 1938
    required that drugs had to be approved by the FDA and demonstrate safety.
  36. Kefauver-Harris Amendment of 1962
    required drugs to actually show proof of efficacy and safety.
  37. Pharmacodynamic
    drug actions/effects on biologic systems
  38. Agonist
    exhibit effects similarly to naturally occurring molecule
  39. Partial Agonist
    Produces less than the full effect, even when it has saturated the receptors.

    It acts as an inhibitor in the presence of a full agonist.

    They have a lower maximal efficacy than a full agonist.
  40. Efficacy
    greatest effect an agonist can produce at highest tolerated dose level taken
  41. Full Agonist
    drug capable of fully activating the effector system when it binds to the receptor
  42. Antagonist
    inhibit the effect to a naturally occurring molecule
  43. Competitive Antagonists
    Drugs that bind to (or close to) the agonist site in a reversible way w/o activating the system.

    IF both the competitive antagonist and the agonist are present, it takes a higher dose of the agonist to fully activate the receptors by displacing the antagonist.
  44. Irreversible Antagonists
    Drugs that bind to the agonist site w/o activating the system.

    IF both the irreversible anatgonoist and agonist are present the agonist cannot overcome the antagonist with a higher dose and instead lowers the effect that the agonist has on the receptors.
  45. Potency
    amount of drug needed to produce a given effect determined mainly by the affinity of the receptor for the drug and the number of receptors available
  46. Pharmacokinetic
    the effect of the biologic system on the drug

    - Absorption, distribution, elimination
  47. Absorption
    Rate absorption depends on administration

    Most PO not completely absorbed

    IV 100% absorption

    Hydrophilic or overly lipophilic can affect the drugs ability to cross the cell membrane or the water layer next to the cell
  48. Distribution
    How effectively the drug distributes to the body is related to the volume of distribution (low is mostly blood, high is extravascular tissue) and if its homogenous
  49. Distribution is affected by:
    Molecular size (IV vs PO)

    Physical volume of the body (hydration/dehydration)

    Protein vs unbound

    Lipophilic/ hydrophilic factors
  50. Elimination
    Clearance relates the rate of elimination to the plasma concentration (volume/time)

    Mostly done by the kidneys or liver or a combination of the two

    Elimination is usually constant.

    Ideally it takes 5 half -lives for the drugs to be cleared
  51. Half-Life
    The concentration always reaches 50% of steady state after 1 half-life, 75% after 2 half-lives, 87.5% after 3 half-lives, and so on.

    Steady state reached at about 4-5 half-lives
  52. DOSAGE FORMS
    Parenteral:IV, IM

    Oral: tablets, capules, liquid, suspensions

    Rectal: suppositories, enemas, gels

    Topical/Transdermal: patches, creams, ointments, gels, drops, liquids

    Inhalation: powder, liquids, sprays, nebulizers
  53. Low doses can cause ___ effects than larger doses. As the doses get ___ the desired effect diminishes and undesired effects increases.
    larger; higher
  54. 1st pass drugs
    drug goes to liver first before it is distributed throughout the body

    not all drugs go through 1st pass
Author
cheerios258
ID
347262
Card Set
Pharmacology
Description
stems, drug naming, definitions
Updated