H pylori Microbiology

What is the gram stain and shape of H pylori?
- Gram Negative
- Rods (curved to spiral shaped)
Most gastric and duodenal ulcers are due to?

H pylori
What is the major cause of gastric cancer?

H pylori
What is the optimum pH for H pylori, how does it maintain that in stomach?
- Optimum pH of 6-7
- Urease + to help
H pylori is urease _____, oxidase ____, catalase___, nitrite___.
- +
- +
- +
- +
True/false: H pylori is nonmotile

False; they have flagella which help them move to the lower parts of the stomach on the epithelial side
What are major virulence factors of H pylori?
- Urease (create more high pH for self)
- Flagella
- LPS (because gram negative)
- Lipid A.
- O side chain antigenic variation ---lead to genetic diversity
- Exotoxin cagA, vacA
- Adhesins
What are the exotoxins produced by H pylori?
- cagA
- vacA
Untreated H pylori can manifest clinically with?
- gastric adenocarcinoma
- Marginal zone B cell lymphoma of MALT type
What are noninvasive diagnostic methods for H pylori?
- Stool antigen testing
- Urea breath test (Expensive but more rapid)
What is an invasive diagnostic method for H. pylori?
- Biopsy urease test
- Culture biopsy specimen

Author

lykthrnn

346846

Card Set

H pylori Microbiology

Description

GI Midterm- Microbiology

Updated

2019-05-09T01:32:42Z

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