Bio 99 Midterm 1 Lec: 7

  1. Mutations are
    changes in DNA sequence that are propagated through successive cellular generations.
  2. In multi-cellular eukaryotes, must distinguish between ______ and ______ mutations
    • somatic cell
    • germ-line
  3. Types of mutations
    • a)Single base pair
    • b)Small insertions/deletions
    • c)Large chromosomal rearrangements
  4. Consequences for mutations
    • a)Bad –protein not expressed or non-functional
    • b)Silent – small or no functional effect –> polymorphisms
    • c)Good – evolution (rare)
  5. Sources of mutation
    • 1.Errors during replication
    • 2.Chemical damage to nucleotides
    • 3.Small insertions/deletions
    • 4.Large chromosomal rearrangements
  6. Agents of damage
    • 1.UV light; a)direct oxidation
    • 2.reactive oxygen species
    • 3.Hydrolysis
    • 4.Alkylating agents
  7. Ames Test: purpose
    • a widely employed method that uses bacteria to test whether a given chemical can cause mutations in the DNA of the test organism. 
    • developed test based on particular salmonella strand w/ mutations
Author
jocelyn0399
ID
346786
Card Set
Bio 99 Midterm 1 Lec: 7
Description
bio99
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