Bio 99 Midterm 1 Lec: 6

  1. Control of cell cycle:
    CDK/cyclin system
  2. CDKactivation by cyclin
    Image Upload 1
  3. Pre-replication Complex (preRC) formation is _________
    cell cycle dependent
  4. preRC forms in __ phase
    G1
  5. RC activated in __ phase
    S
  6. Why must replication be regulated?
    • •Very costly (energy) – only perform when necessary, have the appropriate nutrients and cell size
    • •Only can happen once per cell cycle – aneuploidy can negatively impact cell/organism
  7. DNA in the cell is _______
    supercoiled
  8. _________ alter the degree of supercoiling
    Topoisomerases
  9. After the unbroken strand passes through the nick in the DNA to relieve supercoiling, how is the nicked DNA strand made intact again?



    A.
  10. End Replication Problem
    How do you replicate the end of DNA?
    • telemerase
    • recognizes the repeated sequence
  11. The End Replication Problem occurs because:



    D.
  12. Shortening of telomeric DNA during cell proliferation
    Telomeric DNA gets shorter and shorter throughout the successive cell generations
  13. Protection of chromosme ends
    Image Upload 2
  14. Structure of the t-loop
    • shelterin complex
    • multiple telomere-specific proteins bind to telomeric DNA
Author
jocelyn0399
ID
346785
Card Set
Bio 99 Midterm 1 Lec: 6
Description
bio99
Updated