Diabetic Infections Microbiology

  1. Which is the most common microbial etiology of necrotizing otitis externa?
    Pseudomonas aeruginosa
  2. Pseudomonas is gram _______. Oxidase ______. _______fermenter.
    • Negative
    • Positive
    • Non
  3. True/false: pseudomonas is the only clinical bacteria with Algina capsule
  4. True/false: pseudomonas is facultative anaerobe
    False; obligate aerobes
  5. Is pseudomonas part of normal microbiota?
  6. Where is pseudomonas often found?
    Water and hot tubs, though ubiquitous.
  7. How would pseudomonas appear on MacConkey plate?
    Would not be pink because they don’t ferment lactose
  8. Which microbe gives off grape odor?
  9. Which microbe can produce blue (pyocytanin) or green (pyoverdine) pigement?
  10. What are virulence factors of pseudomonas?
    • Pili
    • Alginate capsule
    • Spreading factors
    • Exotoxin A
    • Biofilm formation
    • Abx resistance
  11. What are the spreading factors of pseudomonas?
    • collagenase
    • Elastase
    • Phospholipase (Beta hemolysis)
    • Protease
  12. Which organisms have increased risk for skin and mucosal colonization?
    • S aureus
    • Candida
  13. True/false: Ketones are toxic to micrboes
  14. Which microbe have ketone reductase, therefore able to reduce ketone to alcohol
  15. Which microbe have glucose inducible adhesins?
    Candida albicans
  16. What is the treatment regimen for necrotizing otitis externa?
    surgical debridement and antibacterial therapy
  17. What is the primary pathogen for most diabetic foot infections?
  18. For severe diabetic foot infections, what are the treatment procedure?
    • Prompt surgical debridement
    • Obtain deep tissue cultures prior to empiric therapy
    • Broad spectrum until culture returns
    • Possible revascularization or amputation
  19. Type 1 necrotizing fasciitis is ____, type 2 necrotizing fasciitis is ____
    • Polymicrobial
    • Monomicrobial
  20. Which type of necrotizing fasciitis most often occur to DM patients? Which type occurs from trauma?
    • Type 1 for DM pts
    • Type 2 from trauma
  21. What is the common microbial organisms causing type 2 necrotizing fasciitis?
    Streptococcus pyogenes
  22. Head and neck (aka cervical nec fasc) most often origin?
    Dental origin
  23. True/false: cervical necrotizing fasciitis is a type 2 nec fasc
    False; it is type 1
  24. What is the treatment protocol for type 1 nec fasc?
    Immediate and complete surgical debridement + abx + supportive therapy + diabetes control
  25. True/false: Rhizopus is an opportunistic, non-dimorphic mold
  26. How is Rhizopus transmitted?
    Airborne spore inhalation
  27. True/false: Rhizopus is septated
    False; lack septation
  28. True/false: Rhizopus is angiotropic, has hyphae and requires lot of iron
  29. Describe the transmission and pathogenesis of rhinocerbral mucormyocsis:
    • Inhalation sporangiospore
    • Germination in nasal passages
    • Invasion hyphae into blood vessels
    • Invasion sinuses, eyes, cranial bones, brain
    • Thrombosis, infarction, necrosis
  30. Treatment for rhinocerebral mucormycosis?
    • Aggressive surgical debridement
    • IV lipid amphotericin B
    • Control of diabetes
  31. Mucormycosis classically affects which patient population?
    Diabetics with ketoacidosis because Rhizopus has affinity for acidic environments
Card Set
Diabetic Infections Microbiology
Renal Final- Microbiology