Immunology 6

  1. Four characteristics of specialization
    • cytokines that induce differentiation
    • transcription factors that determine differentiation
    • cytokines that the T cell makes
    • cells that the T cells "work" on
  2. four main specialized T cells
    TH1, TH2, TH17, Tregulatory
  3. cytokine that specialize Thelper cells to TH1
    IL-12
  4. where and when is IL-12 produced?
    produced in DC after signal 1
  5. Th1 master regulator transcription factor
    T-bet
  6. What happens after T cells are activated and specialized
    • T cells leave the lymph node and home to infected cell
    • they recognize MHC:peptide in periphery
    • exert effector function
  7. adhesion molecules of t helper cells
    VLA-4 integrin it binds to VCAM-1
  8. Characteristics of CTLs (CD8)
    • produce cytotoxins
    • kill infected cells
    • store cytotoxins in lytic granules
  9. cytotoxins in CTLs
    perforin, granzymes, granulysin
  10. major cytokine in CD8 t cells or CTLs
    IFN-gamma
  11. function of T helper cell cytokines
    activate CD8 cells by altering gene expression
  12. what major signaling pathway do cytokines use to effect transcription of target cells
    JAK/STAT
  13. the purpose of B cells?
    to produce antibodies
  14. function of antibodies
    • neutralization of pathogens
    • opsonization
    • complement activation
  15. where does B cell development take place
    bone marrow and after activation in the lymph nodes
  16. what happens after B cells are activated and proliferated
    they become plasma cells or memory B cells
  17. first antibody to be expressed
    IgM
  18. positive selection of B cell development
    cells that successfully make Ig by combining an H and L gene
  19. how does B cell know that it successfully created an Ig
    When Ig is trafficked to the membrane it associates with 2 Ig factors and the cluster initiates a survival signal
  20. negative selection of B cells
    Igs that bind too tightly
  21. signal 1 for B cell development
    crosslinking of multiple surface Ig molecules by a multimeric antigen
  22. signal 2 for B cell activation
    • when it recognize an antigen it endocytosis it and presents it on MHC class 2 for a helper T cell to recognize 
    • CD40 on B cell bind CD40L on T cell
  23. T-independent signal 2 activation on B cells
    in the case of an antigen recognition and PRR B cell stimulation
Author
Sheilaj
ID
346202
Card Set
Immunology 6
Description
lec 14 and lec 15
Updated