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Acute phase proteins

  1. Examples - 9 total, say 3
    • - CRP
    • - procalcitonin
    • - ferritin
    • - fibrinogen
    • - alpha-1 antitrypsin
    • - caeruloplasmin
    • - serum amyloid A
    • - haptoglobin
    • - complement
  2. What is negative acute phase proteins? examples (5)
    During acute phase response, liver DECREASES production of other proteins: 


    Examples include:

    • - albumin
    • - transthyretin (formerly known as - prealbumin)
    • - transferrin
    • - retinol binding protein
    • - cortisol binding protein
  3. CRP is synthesised where? binds what? then do what?
    • - a protein synthesised in the liver
    • - binds to phosphocholine in bacterial cells and on those cells undergoing apoptosis
    • - then activate complement system
  4. What happens to CRP levels in pt following surgery? When abnormal?
    • - Known to rise 
    • - >150 at 48h post op -> evolving complications
Author
trincam2008
ID
346183
Card Set
Acute phase proteins
Description
MRCS Physiology acute phase proteins
Updated

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