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characteristics of collagen fibers
- over 29 types, mostly fibrillar, type I is most prominent (over 20% body protein)
- tough, inelastic, tougher than steel
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connective tissue function
provides structural support (connects bone to bone-ligaments, connects mm to bone-tendons, connects muscle to muscle-aponeuroses, underlies epithelium)
established immunological barrier
provides energy storage and water storage
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collage type I
most abundant in body
tendons, skin, artery walls, muscular fascia, fibrocartilage, bones, teeth
*osteogenesis imperfecta, Ehlers-Danlos syndrome
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collagen II
found in hyaline cartilage, vitreous humor, 50% of all cartilage protein
*collagenopathy types II and XI
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type III collagen
reticular fubers
found in artey walls, skin, intestines and uterus
*ehlers-danlos syndrome
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collagen type IV
- basal lamina of all epithelia, eye lens
- globular protein, NOT a fiber!
*Alport syndrome
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type VII collagen
anchoring fibrils in epidermal junctions
*epidermolysis bullosa
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