Drugs for Influenza

  1. What are influenza drug targets?
    • M2 protein
    • Neuraminidase
    • Viral RNA synthesis Replication
  2. Which anti-viral drugs are M2 ion channel blockers?
    • Amantadine
    • Rimantadine
  3. What is the mechanism of action for amatadine?
    M2 ion channel blocker
  4. What is the mechanism of action for rimantadine?
    M2 ion channel blocker
  5. Which type of influenza do M2 ion channel blockers have effect on?
    Influenza A only
  6. True/False: amantadine is a M2 ion channel blocker for both types A and B influenza
    False; type A only
  7. True/False: Rimantadine is a M2 ion channel blocker for Type A influenza only.
    True; amantadine, too
  8. What is the mechanism of action for osteltamivir?
    Neuraminidase inhibitor
  9. What is the mechanism of action for zanamivir?
    Neuraminidase inhibitor
  10. What is the mechanism of action for peramivir?
    Neuraminidase inhibitor
  11. What is the route of administration for osteltamivir?
    Oral
  12. What is the route of administration for zanamivir?
    Inhalation
  13. What is the route of administration for peramivir?
    IV
  14. What type(s) of influenza do neuraminidase inhibitors have effect on?
    • Both types A and B
    • List three neuraminidase inhibitors:
    • Oseltamivir
    • Zanamivir
    • Peramivir
  15. Which is an oral neuraminidase inhibitor
    Osteltamivir
  16. Which is an inhaled neuraminidase inhibitor
    Zanamivir
  17. Which is an intravenous neuraminidase?
    Peramivir
  18. Oseltamivir is an ____ anti-viral drug that targets _______ influenza by _______
    Oral; types A and B; inhibiting neuraminidase
  19. Zanamivir is an ____ anti-viral drug that targets _______ influenza by _______
    Inhaled; types A and B; inhibiting neuraminidase
  20. Peramivir is an ____ anti-viral drug that targets _______ influenza by _______
  21. Intravenous; types A and B; inhibiting neuraminidase
  22. Which is a cap-dependent endonuclease inhibitor?
    Baloxavir
  23. What is the mechanism of action for baloxavir?
    • Endonuclease inhibitor
    • Inhibit viral RNA transcription and blocks virus replication
  24. What is the route of administration for baloxavir?
    Oral
  25. What type of influenza do baloxavir target?
    Both types A and B
  26. True/False: only amantadine and rimantadine are ant-viral drugs that don’t effect Type B influenza
    True
  27. What is the function of the M2 protein?
    Allows for viral uncoating
  28. True/False: majority of influenza A viruses are resistant to M2 ion channel blockers
    True
  29. What is the function of neuraminidase?
    Allows for virion release
  30. True/False: Influenza antivirals can be use for chemoprophylaxis
    True
  31. How could Influenza antiviral be used as prophylaxis in otherwise healthy pt and how does affect symptom duration?
    Use within 48 hours of onset of symptoms; can shorten duration by about 1 day
  32. True/False: in hospitalized patients, oseltamivir is still a good prophylaxis for influenza
    False; no evidence of effect on hospitalization
  33. What is the suggested time frame to start antiviral treatment for influenza?
    Within 48 hours of symptom onset
  34. True/False: antiviral treatment might still be beneficial in patients with severe, complicated or progressive illness and in hospitalized patients when given AFTER 48 hours
    True
  35. True/false: Peramivir and Baloxavir are treatment only, not for prophylaxis
    True
  36. Which of the neuraminidase inhibitor is only for treatment but not recommended for prophylaxis?
    Peramivir
  37. Is endonuclease inhibitor recommended for prophylaxis?
    No, baloxavir not recommended for prophylaxis
  38. What is the recommended treatment duration for oral oseltamivir and inhaled zanamivir
    5 days
  39. What is the recommended treatment duration for IV peramivir or oral baloxavir?
    Single dose
  40. What is the recommended treatment duration for patients who remains severely ill after 4 days of treatment
    Longer daily dosing for oral oseltamivir or IV peramivir
  41. What are adverse effects of oseltamivir?
    • nausea, vomiting
    • Skin reaction
    • Neuropsychiatric evens in Japanese
Author
lykthrnn
ID
345752
Card Set
Drugs for Influenza
Description
Pulmonary Finals- Pharmacology
Updated