Drugs for Influenza

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What are influenza drug targets?
- M2 protein
- Neuraminidase
- Viral RNA synthesis Replication
Which anti-viral drugs are M2 ion channel blockers?
- Amantadine
- Rimantadine
What is the mechanism of action for amatadine?

M2 ion channel blocker
What is the mechanism of action for rimantadine?

M2 ion channel blocker
Which type of influenza do M2 ion channel blockers have effect on?

Influenza A only
True/False: amantadine is a M2 ion channel blocker for both types A and B influenza

False; type A only
True/False: Rimantadine is a M2 ion channel blocker for Type A influenza only.

True; amantadine, too
What is the mechanism of action for osteltamivir?

Neuraminidase inhibitor
What is the mechanism of action for zanamivir?

Neuraminidase inhibitor
What is the mechanism of action for peramivir?

Neuraminidase inhibitor
What is the route of administration for osteltamivir?

Oral
What is the route of administration for zanamivir?

Inhalation
What is the route of administration for peramivir?

IV
What type(s) of influenza do neuraminidase inhibitors have effect on?
- Both types A and B
- List three neuraminidase inhibitors:
- Oseltamivir
- Zanamivir
- Peramivir
Which is an oral neuraminidase inhibitor

Osteltamivir
Which is an inhaled neuraminidase inhibitor

Zanamivir
Which is an intravenous neuraminidase?

Peramivir
Oseltamivir is an ____ anti-viral drug that targets _______ influenza by _______

Oral; types A and B; inhibiting neuraminidase
Zanamivir is an ____ anti-viral drug that targets _______ influenza by _______

Inhaled; types A and B; inhibiting neuraminidase
Peramivir is an ____ anti-viral drug that targets _______ influenza by _______
Intravenous; types A and B; inhibiting neuraminidase
Which is a cap-dependent endonuclease inhibitor?

Baloxavir
What is the mechanism of action for baloxavir?
- Endonuclease inhibitor
- Inhibit viral RNA transcription and blocks virus replication
What is the route of administration for baloxavir?

Oral
What type of influenza do baloxavir target?

Both types A and B
True/False: only amantadine and rimantadine are ant-viral drugs that don’t effect Type B influenza

True
What is the function of the M2 protein?

Allows for viral uncoating
True/False: majority of influenza A viruses are resistant to M2 ion channel blockers

True
What is the function of neuraminidase?

Allows for virion release
True/False: Influenza antivirals can be use for chemoprophylaxis

True
How could Influenza antiviral be used as prophylaxis in otherwise healthy pt and how does affect symptom duration?

Use within 48 hours of onset of symptoms; can shorten duration by about 1 day
True/False: in hospitalized patients, oseltamivir is still a good prophylaxis for influenza

False; no evidence of effect on hospitalization
What is the suggested time frame to start antiviral treatment for influenza?

Within 48 hours of symptom onset
True/False: antiviral treatment might still be beneficial in patients with severe, complicated or progressive illness and in hospitalized patients when given AFTER 48 hours

True
True/false: Peramivir and Baloxavir are treatment only, not for prophylaxis

True
Which of the neuraminidase inhibitor is only for treatment but not recommended for prophylaxis?

Peramivir
Is endonuclease inhibitor recommended for prophylaxis?

No, baloxavir not recommended for prophylaxis
What is the recommended treatment duration for oral oseltamivir and inhaled zanamivir

5 days
What is the recommended treatment duration for IV peramivir or oral baloxavir?

Single dose
What is the recommended treatment duration for patients who remains severely ill after 4 days of treatment

Longer daily dosing for oral oseltamivir or IV peramivir
What are adverse effects of oseltamivir?
- nausea, vomiting
- Skin reaction
- Neuropsychiatric evens in Japanese

Author

lykthrnn

345752

Card Set

Drugs for Influenza

Description

Pulmonary Finals- Pharmacology

Updated

2019-03-04T17:05:25Z

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