Drugs for Tuberculosis

Home

Get App

Create

What are the first line active TB treatment drugs?
- Rifampin
- Isoniazid
- Pyrazinamide
- Ethambutol
For the first 2 months of infections, which drugs should the patient be on for active TB treatment?
- All 4: RIPE
- Rifampin
- Isoniazid
- Pyranzinamide
- Ethambutol
After the first two months of therapy for active TB, what should the regimen be like for the next 5 or so months?

On 2+ drugs of the 4: usually Rifampin and Isoniazid
What is standard therapy for Latent TB treatment?

9 months of daily INH
True/False: chemo prophylaxis is in order for latent TB in order to prevent active infection

True
What is direct observation of therapy?

Providing anti TB drugs directly to the patient and watching as pt swallows the medications
What is the purpose behind direct observation of therapy?

Make sure pt is compliant so to avoid drug resistant TB from developing
True/False: majority of TB in the US are drug resistant

False; they are sensitive to first line tx: RIPE
What is the mechanism of action for rifampin?

Inhibit RNA polymerization
What is the mechanism of action for isoniazid?

Inhibits mycolic acid synthesis
What is the mechanism of action for pyrazinamide?

Unknown! Ha.
What is the mechanism of action for ethambutol?

Inhibits cell wall synthesis
Which of the first line drug’s mechanism of action has to do with inhibiting cell wall synthesis?
- Isoniazid (mycolic acid)
- Ethambutol
Which first line drug’s mechanism of action is to inhibit RNA synthesis?

Rifampin
True/False: we do not really know the mechanism of action of pyrazinamide?

True
What are the adverse effects for rifampin?
- Hepatitis
- GI upset
- Orange colored body fluids
- Significant drug interactions
What are adverse effects for isoniazid?
- Hepatitis
- Peripheral neuropathy
What are adverse effects for pyrazinamide?
- Nausea
- Hepatitis
- Rash
- Joint ache
- Hyperuricemia
What are adverse effects for ethambutol?
- Optic neuritis with blurred vision
- Red green color blindness
Which of the first line drug has significant drug-drug interaction?

Rifampin
Which of the first line drugs can cause drug-induced hepatitis?
- INH (isoniazid)
- Rifampin
- Pyrazinamide
Which of the first line drugs can cause neurotoxicity?

isoniazid
How can neurotoxicity be prevented as a side effect of isoniazid?

Taking Vitamin B6 at the same time
What is pyridoxine?

Vitamin B6
Which of the rifamycin antimicrobial group does not have drug interactions?

Rifaximin
True/false: when rifampin is used as a single agent treatment, bacteria develop drug resistant

True
True/flase: isoniazid can turn nbody fluids into orange

False; it is rifampin
Which drug is seen with “red man syndrome” of skin discoloration

Rifampin

Author

lykthrnn

345743

Card Set

Drugs for Tuberculosis

Description

Pulmonary Final- Pharmacology

Updated

2019-03-04T04:59:57Z

Show Answers