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gene segements a part of BCR gene
variable, diversity, and joining segments
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do all cells have immunoglobulin loci
yes, but only B cells can perform random rearrangement because they only express RAG enzyme
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2 another name for BCRs
immunoglobulins and antibodies
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name for secreted BCR
antibody
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where is B cell diversity generated
bone marrow
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where is T cell diversity generated
thymus
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what types of epitopes can TCRs recognize
linear
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what cells do MHC Class I present to
CD8 killer cells
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what cells express MHC class I
ubiquitously expressed by all cells
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what cells do MHC Class II present
CD4 helper T cells
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what cells express MHC class II
antigen presenting cells
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professional antigen presenting cells
- B cells, macrophages, and dendritic cells
- they express both MHCs and can activate both CD8 and CD4
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synonym for human MHC
HLA
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how is the signal from T-Cell antigen binding inititated
through iTAMS on CD3
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how are immunoproteosomes formed
formed in the cytosol due to expression of certain cytokines during innate response to pathogens
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difference between proteosomes and immunoproteosomes
immuno speed up peptide release
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how do small peptides reach MHC class I
intracellular/endogenous antigens are degraded by immunoprot and transported to ER through TAP and bind to MHC
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how do small peptides reach MHC class II
extracellular/exogenous antigens are engulfed and fuse with lysosome where they are degraded and then they fuse with vesicle containing MHC class II
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cross presentation
ability for exogenously processed antigens to be presented to MHCII and MHC I and activate CD8 and CD4 cells
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isotypes of human MHC class II
DP, DQ, and DR
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isotypes of human MHC class I
A B C
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haplotype
genetic profile(polymorphisms) of a specific allele of a gene family
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isotypes
protein products from different genes within a gene family
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allele
different form of a gene
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allotype
protein products from alleles
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anchor residues
the residues of the antigen that bind directly to MHC
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MHC restriction
specific binding of TCR to peptide + self MHC
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chemokine for neutrophil
CXCL8
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adhesion molecules for neutriphil
- LFA-1 integrin on neitrophil membrane
- ICAM-1 on blood vessel wall
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where do mature T cells go when they leave the thymus
to blood stream where they bind to adhesion molecule on HEV
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HEV
endothelial blood vessel cells near lymph nodes
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chemokine receptor on T cell
CCR7
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chemokine for T-cell
CCL19 and CCL21
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two sites of lymphoid activation
spleen and lymph nodes
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