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Immunology 4
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gene segements a part of BCR gene
variable, diversity, and joining segments
do all cells have immunoglobulin loci
yes, but only B cells can perform random rearrangement because they only express RAG enzyme
2 another name for BCRs
immunoglobulins and antibodies
name for secreted BCR
antibody
where is B cell diversity generated
bone marrow
where is T cell diversity generated
thymus
what types of epitopes can TCRs recognize
linear
what cells do MHC Class I present to
CD8 killer cells
what cells express MHC class I
ubiquitously expressed by all cells
what cells do MHC Class II present
CD4 helper T cells
what cells express MHC class II
antigen presenting cells
professional antigen presenting cells
B cells, macrophages, and dendritic cells
they express both MHCs and can activate both CD8 and CD4
synonym for human MHC
HLA
how is the signal from T-Cell antigen binding inititated
through iTAMS on CD3
how are immunoproteosomes formed
formed in the cytosol due to expression of certain cytokines during innate response to pathogens
difference between proteosomes and immunoproteosomes
immuno speed up peptide release
how do small peptides reach MHC class I
intracellular/endogenous antigens are degraded by immunoprot and transported to ER through TAP and bind to MHC
how do small peptides reach MHC class II
extracellular/exogenous antigens are engulfed and fuse with lysosome where they are degraded and then they fuse with vesicle containing MHC class II
cross presentation
ability for exogenously processed antigens to be presented to MHCII and MHC I and activate CD8 and CD4 cells
isotypes of human MHC class II
DP, DQ, and DR
isotypes of human MHC class I
A B C
haplotype
genetic profile(polymorphisms) of a specific allele of a gene family
isotypes
protein products from different genes within a gene family
allele
different form of a gene
allotype
protein products from alleles
anchor residues
the residues of the antigen that bind directly to MHC
MHC restriction
specific binding of TCR to peptide + self MHC
chemokine for neutrophil
CXCL8
adhesion molecules for neutriphil
LFA-1 integrin on neitrophil membrane
ICAM-1 on blood vessel wall
where do mature T cells go when they leave the thymus
to blood stream where they bind to adhesion molecule on HEV
HEV
endothelial blood vessel cells near lymph nodes
chemokine receptor on T cell
CCR7
chemokine for T-cell
CCL19 and CCL21
two sites of lymphoid activation
spleen and lymph nodes
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Author
Sheilaj
ID
345541
Card Set
Immunology 4
Description
lec 7 and lec 8
Updated
2019-02-25T01:58:35Z
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