Immunology 4

  1. gene segements a part of BCR gene
    variable, diversity, and joining segments
  2. do all cells have immunoglobulin loci
    yes, but only B cells can perform random rearrangement because they only express RAG enzyme
  3. 2 another name for BCRs
    immunoglobulins and antibodies
  4. name for secreted BCR
  5. where is B cell diversity generated
    bone marrow
  6. where is T cell diversity generated
  7. what types of epitopes can TCRs recognize
  8. what cells do MHC Class I present to
    CD8 killer cells
  9. what cells express MHC class I
    ubiquitously expressed by all cells
  10. what cells do MHC Class II present
    CD4 helper T cells
  11. what cells express MHC class II
    antigen presenting cells
  12. professional antigen presenting cells
    • B cells, macrophages, and dendritic cells
    • they express both MHCs and can activate both CD8 and CD4
  13. synonym for human MHC
  14. how is the signal from T-Cell antigen binding inititated
    through iTAMS on CD3
  15. how are immunoproteosomes formed
    formed in the cytosol due to expression of certain cytokines during innate response to pathogens
  16. difference between proteosomes and immunoproteosomes
    immuno speed up peptide release
  17. how do small peptides reach MHC class I
    intracellular/endogenous antigens are degraded by immunoprot and transported to ER through TAP and bind to MHC
  18. how do small peptides reach MHC class II
    extracellular/exogenous antigens are engulfed and fuse with lysosome where they are degraded and then they fuse with vesicle containing MHC class II
  19. cross presentation
    ability for exogenously processed antigens to be presented to MHCII and MHC I and activate CD8 and CD4 cells
  20. isotypes of human MHC class II
    DP, DQ, and DR
  21. isotypes of human MHC class I
    A B C
  22. haplotype
    genetic profile(polymorphisms) of a specific allele of a gene family
  23. isotypes
    protein products from different genes within a gene family
  24. allele
    different form of a gene
  25. allotype
    protein products from alleles
  26. anchor residues
    the residues of the antigen that bind directly to MHC
  27. MHC restriction
    specific binding of TCR to peptide + self MHC
  28. chemokine for neutrophil
  29. adhesion molecules for neutriphil
    • LFA-1 integrin on neitrophil membrane
    • ICAM-1 on blood vessel wall
  30. where do mature T cells go when they leave the thymus
    to blood stream where they bind to adhesion molecule on HEV
  31. HEV
    endothelial blood vessel cells near lymph nodes
  32. chemokine receptor on T cell
  33. chemokine for T-cell
    CCL19 and CCL21
  34. two sites of lymphoid activation
    spleen and lymph nodes
Card Set
Immunology 4
lec 7 and lec 8