1. Home
  2. Flashcards
  3. Preview

Immunology 3

  1. What mediates the initial sensing of a challenge
    pattern recognition receptors
  2. what is a molecular pattern
    shared molecular features that allow the immune system to identify a category of organism and/or potential threat
  3. two main types of molecular patterns
    PAMPS and DAMPS
  4. what are PAMPS
    • pathogen associated molecular patterns
    • produced only by microbes
    • compounds that are fundamental to integrity, survival, and/or pathogenicity of microbe
  5. what are DAMPS
    • produced by host cells that have undergone damage
    • compounds that are not normally accessible to immune recognition
  6. what are alarmins
    DAMPS
  7. Essential PAMP from bacteris
    LPS-lipopolysaccharide
  8. example of DAMPS
    • necrosis
    • injury
  9. what is necrosis
    unprogrammed cell death
  10. 4 major families of PRR
    • Toll-like Receptors
    • C-type Lectin
    • NOD-like Receptors
    • Rig-I-like Receptors
  11. Function of TLR4
    major PRR for detecting LPS
  12. 4 locations of PRRs
    Soluble, within vesicles, cytoplasmic, membrane-bound
  13. what is apoptosis
    programmed cell death
  14. PRRs activate immunological responses that are tailored to the type of threat they recognize
    remember this
  15. two main groups of leukocytes
    lymphoids and myeloid
  16. key cells in adaptive immunity
    • B and T cells (lymphoid)
    • Dendritic cell (myeloid)
  17. 3 key functions of DCs
    • sentinels - to detect danger
    • initiate - T lymphocyte activation
    • direct - the course of the immune response
  18. How do DCs intiate T cell activation
    they present antigens to T and B cells
  19. what is an antigen
    a specific compound that is recognized by the receptor of a B or T lymphocyte
  20. where do T cells and B cells spend much of their time
    lymph nodes and spleen
  21. how are antigens brought to the lymph nodes
    lymphatic fluid
  22. what is the structure and make up of lymph nodes
    B cells, T cells and other cell types are arranged into zones that help the cells communicate in an organized way
  23. where are DCs found throughout the body
    near the body surfaces
  24. what do DCs do when they are activated
    • take up materials from the local environment
    • present antigens at cell - surface
    • Migrate to lymph nodes
    • Up-regulate co-stimulatory molecules that activate T lymphocytes
  25. central requirement for initial activation of lymphocyte
    • recognitition of cognate antigen by antigen receptor
    • co-stimulation provided by other receptors
Author
Sheilaj
ID
345251
Card Set
Immunology 3
Description
Lec 5-6
Updated

  1. Home
  2. Flashcards
  3. Preview