Angina Drugs

  1. What is angina pectorals?
    Chest discomfort due to myocardial ischemia
  2. Which category does unstable angina belong to?
    Acute coronary syndromes
  3. What is another name for stable angina?
    Exertion also angina
  4. Is there presence of plaque in stable angina?
    Yes, lumen narrowed by plaque
  5. What causes pain in stable angina?
    Inappropriate vasoconstriction
  6. What distinguish unstable angina form stable angina?
    • Unstable angina has ruptured plaque
    • Platelet aggregation and thrombus fomration
  7. In variant angina, is there plaque formation?
    No, no overt plaques
  8. Main angina therapy targets what?
    Myocardial oxygen consumption. Work to decrease wall stress, heart rate and contractility
  9. What is the preferred route of administration for organic nitrates?
  10. What affect on myocardial oxygen consumption does nitrate have?
    Decrease end diastolic pressure thereby decreasing preload and wall stress
  11. What are the therapeutic uses for nitrates?
    • Stable angina
    • Variant angina
    • Unstable angina
  12. What are adverse effects of nitrates?
    • Throbbing headache (due to cerebral vessels dilation)
    • Tachycardia
  13. What is a contraindication for nitrates?
    Viagra (aka PDE-5 inhibitor)
  14. What are two Ca2+ channel blockers we learned?
    • Verapamil
    • Diltiazem
  15. What is a physiologic effect of Ca2+ channel blocker use?
    • Leads to reduction in contractility
    • Dilation vascular smooth muscle —> decrease PVR, decrease after load and myocardial O2 demand
  16. True/False: Dihydropyridines have most effect on cardiac tissue
    False, not much effect on cardiac tissue, more effects at vascular smooth muscle dilation
  17. What is a common side effect with verapamil?
  18. What is an adverse effects with Ca2+ channel blockers?
    Cardiac depression – cardiac arrest, bradycardia, AV block, heart failure
  19. What is a contraindication for Ca2+ channel blockers?
    Heart failure
  20. What is the mechanism of action for beta blockers?
    Blocks sympathetic activation
  21. What are some agents of beta blockers treatment for stable angina?
    • Propranolol
    • Metoprolol
    • Atenolol
  22. What are adverse effects for beta blocker?
    • Fatigue
    • Impotence
    • Lethargy
    • Insomnia
  23. What are contraindication for beta blocker
    • Asthma
    • Bradycardia
  24. What is a therapeutic use for ranolazine?
    Chronic angina
  25. What is the route of administration for ranolazine?
  26. What are adverse effects of ranolazine?
    • Dizziness
    • Nausea
Card Set
Angina Drugs
Cardiovascular Final