What is the mechanism of action for Statins?
Inhibit rate limiting enzyme HMG-CoA reductase— cholesterol synthesis
Is there an increase or decrease of LDL receptor with the use of statin?
Increase LDL receptors and thus LDL uptake
Does cholesterol increase or decrease with Statin use?
What is the most effective drug to reduce LDL?
What is the most common adverse effect with statin use?
What are some adverse effects that can occur with statin use?
What are some contraindications for statin use?
Women who are pregnant and lactating
What is the name of a sterol absorption inhibitor?
What is the mechanism of action for ezetimibe?
Reduce absorption of cholesterol through NPC1L1 protein
Ezetimibe is often used with which other drug for an additive effect of reducing cholesterol?
What is an adverse effect of ezetimibe?
Low incidence of hepatic dysfunction
Where are bile salts synthesized?
In the liver
What is the importance of bile salts?
Absorption of fats and remove toxin from body
What is the mechanism of action of bile acid sequestrants?
Prevent absorption of bile acids through intestine thereby increasing excretion of bile acids through feces
Decrease cholesterol hepatocyte
Is there an increased or decreased of LDL receptors with bile acid sequestrants use?
Increased LDL receptors
What are the names of some bile acid sequestrants?
What are some adverse effects of bile acid sequestrants?
Constipation and bloating
Vitamin K deficiency
What are some contraindications for bile acid sequestrants?
Avoided in patients with diverticulitis
What is the mechanism of action for fibrates?
Activate PPAR alpha receptor in the nucleus
What results with fibrates use?
Increase in plasma HDL
Decrease in plasma trigylcerides
What is a contraindication for fibrates?
Patients with renal or hepatic dysfunction
What is niacin?
What’s the mechanism of action of niacin?
Inhibits adipose hormone-sensitive lipase
What results with the use of niacin?
Decrease LDL and VLDL, and slight increase in HDL
What is an adverse effect of niacin?
What can reduce the flushing effect caused by niacinjQuery112406838657385959817_1548649819818
Taking NSAIDs before
What is the mechanism of action of PCSK9 inhibitors?
Inhibits PCSK 9 which leads to decrease LDL
What is the mechanism of action for omega 3 fatty acids?
Regulation of SREBP-1c and PPAR alpha