-
Sinemet
Sinemet CR
- Carbidopa/Levodopa
- IR start dose: 25/100mg TID
- CR start dose: 50/200mg BID
- CR can be cut in half, dont crush or chew
- need 70-100mg of carbidopa to inhibit dopa
-
Rytary
- Carbidopa/Levodopa ER cap
- Start at 23.75/95mg TID if levo naive
- can take whole or sprinkle on applesauce
- SE: suicidal ideation and attempts
-
Duopa
- Carbidopa/Levodopa enteral susp through J-tube
- SE: GI complications
-
Comtan
- Entacapone
- 200mg with each dose of sinemet
- max 1600mg/day
-
Stalevo
- Sinemet + entacapone
- 1:4 ratio with 200mg of entacapone
-
Tasmar
- Tolcapone
- not used much d/t hepatotoxicity
-
Mirapex (ER)
- Pramipexole
- IR formulation approved for RLS
- slow titration
-
Requip (XL)
- Ropinerole
- IR formulation approved for RLS
-
Neupro
- Rotigotine patch
- approved for RLS
- remove patch before MRI
- avoid if sensitive/allergies to sulfites
-
Apokyn
- Apomorphine
- taken in addn to other PD meds
- must be started in med office
- for emesis prevention: tigan (trimethobenzamide) or similar antiemetic 3 days prior to dose
-
Eldepryl
Selegiline capsule
-
-
Emsam
- Selegiline patch
- only indicated for depression
- *selegiline is activating, if dosed BID, then take morning and then mid day
-
Azilect
- Rasagiline
- if taken monotherapy, may cause HA, joint pain and indigestion
-
Xadago
- Safinamide
- adjunctive tx to sinemet in pts experiencing off episodes
- may exacerbate psychotic disorders and ophthalmic disorders
-
-
Northera
- Droxidopa
- used for neurogenic orthostatic hypotension
-
Seroquel
- Quetiapine
- antipsychotic of choice for pts with PD, lowest risk of movement disorders
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