Oral Manifestations of Systemic Disease

  1. Disease that results from the lack of an enzyme necessary to process GAGs
  2. Oral manifestations of Mucopolysaccharidosis (3)
    • Macroglossia
    • Gingival hyperplasia (drying due to mouth breathing or medications)
    • Impacted teeth with large follicular spaces and thin enamel
  3. what are the oral manifestations of Hunter Syndrome, a type of Mucopolysaccharidosis (2)
    • Macroglossia
    • Wide-spaced teeth
  4. Disease that presents in patients that lack enzymes that process certain lipids, allowing cellular accumulation of those lipids
    Lipid Reticuloendothelioses
  5. Most common Lipid Reticuloendothelioses
    Gaucher disease
  6. adults with ____ disease have an increased incidence of lymphoma, multiple myeloma
  7. A patient presents with a mixed, ill-defined RL/RO in mandible that is bilateral and diffuse. They also present with gingivitis, bone pain, and anemia and thrombocytopenia. What do they have?
    Gaucher Disease
  8. Diffuse yellowing discoloration of skin and mucosa (most notable in sclera)
  9. Bilirubin has a preference for structures with elastic tissue. So where would we see it in the oral cavity?
    Soft palate
  10. How can u tell between hypercarotenemia, which causes the skin to be yellow-orange and jaundice
    Hypercarotenemia doesn't cause the sclare to change color
  11. What three other considerations must be taken into account when juandice is present
    • Bleeding tendency (Vit K dependent clotting factors)
    • Immune deficiency 
    • Impaired drug metabolism
  12. Amyloidosis can be secondary to what?
    Multiple myeloma
  13. Extracellular deposition of proteinaceous material results in what disease?
  14. Which form of amyloidosis presents with oral changes?
    Systemic form
  15. Disease that presents with macroglossia and waxy nodular lesions noted periocularly
  16. What shows confirmation (80% positive) of amyloidosis
    Rectal mucosal and labial salivary gland biopsy
  17. Patient presents with the following symptoms: 
    poor wound healing, perio disease, capillary fragility, scorbutic gingivitis (gingival edema, erythema, ulceration, spontaneous bleeding) and petechiae on the skin. what is the probable cause?
    Vitamin C deficiency
  18. Vitamin C is responsible for what?
    Collagen synthesis
  19. a patient presents with defective skeletal development, loss of lamina dura, and fibrous dysplasia-like appearance in radiographs. What is the probable cause
    Vitamin D deficiency
  20. What is the most common anemia?
    Iron deficiency anemia
  21. A patient presents with angular chalets, atrophic glossitis (papillae are blunted), mucosal atrophy, fatigue and palpitations. What is the likely diagnosis?
    Iron deficiency anemia
  22. disease that presents wit iron deficiency, glossitis, dysphagia (esophageal webs), spoon shaped, brittle nails
    Plummer-Vinson Syndrome
  23. People with Plummer-Vinson Syndrome have increased incidence of what?
    oral and esophageal squamous cell CA
  24. What are the oral manifestion for cretinism (3)(hypothyroidism in children)
    • Delayed eruption of fully formed teeth
    • Thickened lips
    • Diffuse tongue enlargement
  25. Hypoparathyroidism causes what?
    Serum calcium levels to drop
  26. What are the oral manifestations of hypoparathyroidism (2)
    • Delayed tooth eruption
    • See diffuse brown spots on the teeth due to hypocalcification during tooth development
  27. What is the oral manifestation of hyperparathyroidism
    Diffuse palatal enlargement is common in the secondary to renal disease form
  28. Stones, bones and abdominal groans refers to what disease?
  29. What is the meaning of 
    Abdominal Groans:
    • Stones: renal caluli
    • Bones: "ground glass" appearance of trabeculae, loss of lamina dura of surrounding teeth 
    • Abdominal Groans: duodenal ulcers 

    also psychic moans-- weakness, confusion and dementia develop
  30. Histologically central giant cell granuloma and hyper PTH look the same. What is the way to differentiate ? (3)
    • Blood work (evaluated PTH)
    • Age (CGCG is in kids, hyper PTH in older people)
    • HyperPTH has stones bones and abdominal groans findings
Card Set
Oral Manifestations of Systemic Disease
Final Exam Material