Blood Component Therapy

  1. Platelet Indications
    • Thrombocytopenia
    • Abn Plt. Function
    • MTP
  2. Common Platelet Evaluation Lab Tests
    • Plt Count
    • PFT (aggregometry)

    -NOT BLEEDING TIME!
  3. Do not transfuse platelets with the following rapid platelet destruction conditions
    • ITP (circulating antibodies)
    • DIC
    • TTP, HIT (plasma exchange)
  4. What is Apheresis Platelets
    quantity is approximately that of 5-6 random donor platelets, but from only one donor
  5. What is Random Donor Platelets
    • Random donor
    • Frequently pooled together with 4-6 other donors to provide a larger quantity.
  6. What should the platelet count be for apheresis platelets
    > 3.0 x 1011
  7. What should the platelet count be for a random donor platelet
    >5.5 x 1010
  8. 1 unit of RDP should increase plt count by what?
    5K - 10K
  9. 1 unit of apheresis platelets should increase plt count by what?
    30K - 60K
  10. Platelet transfusion indicators
    • Typical:
    • <10K - standard
    • <50K - Major surgeries

    • High Risk:
    • 100K - brain or optical surgeries
    • Fever & septic (although plts frequently ineffective), coag defects, & intracranial lesions
  11. When would you XM plts?
    >2mL of RBC's

    *One RhIG should protect against 30 units of RDP or 7 apheresis plts. 
  12. What is cryo reduced plasma useful for
    therapeutic exchange for TTP
  13. What is in cryo
    • Fibrinogen
    • F-8
    • F-13
    • vWF
    • Fibrinectin
  14. How much fibrinogen must be in cryo
    > 150 mg/bag (typically has 250)
  15. How much factor 8 must be in cryo
    > 80 IU (typically has 80-120)
  16. Indications for Cryo
    Fibrinogen & F 13 deficiencies
  17. Cryo is not indicated for what disorders
    Hemophilia A and vWD  - When concentrates are available
  18. How much will a unit of cryo increase the platelet count
    5-10 mg/dL

    Frequently cryo in pools of 5, therefore should see an increase 5x this amount (25-50)
  19. Granulocyte apheresis collection process and requirements
    • G-CSF given to donor to produce larger result.
    • 250-600mL
    • RT 24hours
    • Irrradiated 
    • QC: > 1 x 1010
Author
Kwalke12
ID
343617
Card Set
Blood Component Therapy
Description
SBB 562 Blood Component Therapy
Updated