Basal Forebrain Cholinergic System

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What are cholinesterase inhibitors used for?

Alzheimer’s disease
What are the hypotheses as to why cholinesterase inhibitors are used against Alzheimer’s disease?

Alzheimer’s causes degeneration of cholinergic basal nuclei and cholinergic nuclei affect memory
Effect of acetylcholine in Alzheimer’s

Acetylcholine receptor activation limits Tau phosphorylation (causes Alzheimer’s)
Alzheimer’s disease is more a loss of _____________ memories rather than ______________ memories
- Explicit
- Implicit
What are implicit and explicit memories?
- Implicit memories are facts
- Explicit memories are those that require awareness
You need acetylcholine for proper function of __________________ neurons

Cortical pyramidal
How well do cholinesterase inhibitors work? Why?
- Small improvement
- A significant number of neurons need to be lost for symptoms to show
- Better for prevention
Coma is caused by depressed function of…

Either both hemispheres or reticular activating system in the brainstem
Damage to what brain region can cause loss of consciousness?

Ascending brainstem structures
Eye deviation would be towards/away from a cortical destructive lesion

Toward
A cortical destructive lesion would show which symptoms in the eye?

Eyes move transiently beyond midline with head movement
Eye deviation would be towards/away from a cortical irritable lesion

Away from
Eye deviation would be towards/away from a brainstem lesion

Away from
A brainstem lesion would show which symptoms in the eye?

Fixed eyes, do not swing past midline
Control of the pupil resides in the ___________________

Brainstem
What is a decorticate posturing?
- Flexor
- Lower limbs extended upper limbs flexed
Where would the lesion be for a flexor (decorticate) posturing?

Above the red nucleus
What is a decerebrate posturing?

Upper and lower limbs extended

Author

stepha998

343501

Card Set

Basal Forebrain Cholinergic System

Description

ATSU

Updated

2018-11-10T07:13:22Z