PANRE - Infectious Diseases

  1. What is a buffy coat?
    The fraction of an anticoagulated blood sample that  contains most of the white blood cells and platelets following density gradient centrifugation of the blood.

    b36
  2. This is a disease caused by gram negative intracellular bacteria that infects & destroys WBCs.
    Ehrlichiosis
  3. What are the two types of Ehrlichiosis and their vectors of transmission?
    • 1.Human Granulocytic Anaplasma phagocytophylum
    •    Vector: Ixodes tick (same as Lyme dz)

       Causes: Babesiosis, Ehrlichiosis, Lyme (BEL) dz

    •    
    • > remember: BEL palsy caused by Ixodes tick.

    • 2. Human Monocytic Ehrlichiosis (HME)
    •    - Ehrlichia chaffeensis & canis
    •    Vector: Lone Star tick (same as Lyme dz)

       > remember: Texas (Lone Star) is where home (HME) is.


    (p. 482)
  4. What are morulae found in WBCs infected with Ehrlichiosis?
    These are mulberry-shaped aggregates within infected WBCs.

    Appear 5-7 days after infection

    ehrlichia+caffeensis
  5. Symptoms of Ehrlichiosis begin ____ days after tick bite.

    Prodrome of rigors, malaise, & nausea occur, progressing to _________________.
    • a) 7-10 days
    • b) high fever, toxicity, myalgia, headaches

    No rash usually; ± splenomegaly
  6. How is Ehrlichiosis diagnosed?
    • 1. Buffy coat - note morulae within WBCs
    • 2. Increased LFTs
    • 3. Thrombocytopenia & leukopenia
  7. What is the first line tx for Ehrlichiosis?
    Doxycycline

    - also Rifampin, Chloramphenicol
  8. What diagnosis is associated with the pathognomic finding of tetrad inclusions within RBCs?
    - Babesiosis

    RTEmagicC_Blevins_BloodSmearAnalysis_F1.gif
  9. What are the main vectors for Hantavirus?
    Rodents

    - especially the feces and urine of deer mice.

    - Prodromal febrile phase (including severe myalgias); can progress to cardiopulmonary phase; may cause renal failure.
Author
NavyArmy
ID
343460
Card Set
PANRE - Infectious Diseases
Description
Infectious diseases PANRE review.
Updated