-
context: anti-cancer drugs (Richard)
Prednisone
- Pro-hormone
- corticosteroid that inhibits cytokine production
-
context: anti-cancer drugs (Richard)
Tamoxifen
- anti-hormone
- estrogen receptor antagonist for some tissues
-
context: anti-cancer drugs (Richard)
Trastuzumab
- anti-tumor cell surface
- antibody that binds to HER2 on breast cancer cells
-
context: anti-cancer drugs (Richard)
Imatinib
- anti-tumor cell signaling
- inhibits a tyrosine kinase
-
context: anti-cancer drugs (Richard)
Paclitaxel
- anti-mitosis
- inhibits tubulin from depolymerizing
-
context: anti-cancer drugs (Richard)
Methotrexate
- anti-metabolites
- inhibits formation of precursors of nucleotides
-
context: anti-cancer drugs (Richard)
6-Mercaptopurine
- anti-metabolites
- inhibits purine synthesis
-
context: anti-cancer drugs (Richard)
5-fluorouracil
- anti-metabolites
- inhibits DNA/RNA synthesis
-
context: anti-cancer drugs (Richard)
Irininotecan
- anti-metabolites
- inhibits topoisomerase I
-
context: anti-cancer drugs (Richard)
Etoposide
- anti-metabolites
- inhibits topoisomerase II
-
context: anti-cancer drugs (Richard)
Cyclophosphamide
-
context: anti-cancer drugs (Richard)
Cisplatin
- anti-DNA
- cross-links DNA (RNA and protein also)
-
context: anti-cancer drugs (Richard)
Doxorubicin
- anti-DNA
- intercalates into DNA, inhibits topo II
-
context: anti-cancer drugs (Richard)
Bleomycin
- anti-DNA
- formation of free radicals --> damage DNA
-
Context: Defense type 3: Free Radical Scavengers Cells (Richard)
Vitamin A
- beta carotene
- fat-soluble
- Stop chain reaction in lipid concentrated areas (membranes)/ protect against lipid peroxidation
- ex: sweet potatoes, carrots, broccoli, spinach
-
Context: Defense type 3: Free Radical Scavengers Cells (Richard)
Vitamin C
- ascorbic acid
- water soluble
- defense floating around
- ex: citrus, peppers, broccoli, cabbage
-
Context: Defense type 3: Free Radical Scavengers Cells (Richard)
Vitamin E
- alpha tocopherol
- fat soluble
- Stop chain reaction in lipid concentrated areas (membranes)/ protect against lipid peroxidation
- ex: margarine, vegetable oil, wheat germ, green leafy vegetables.
-
context: bacterial treatment (Munson)
Penicillin
- beta-lactam antibiotic
- prevent cross-linking of peptidoglycan cell walls (gram +/-)
-
context: bacterial treatment (Munson)
penams
- beta-lactam antibiotic
- prevent cross-linking of peptidoglycan cell walls (gram +/-)
-
context: bacterial treatment (Munson)
cephalosporins (cephems)
- beta-lactam antibiotic
- prevent cross-linking of peptidoglycan cell walls (gram +/-)
-
context: bacterial treatment (Munson)
monobactams
- beta-lactam antibiotic
- prevent cross-linking of peptidoglycan cell walls (gram +/-)
-
context: bacterial treatment (Munson)
carbapenems
- beta-lactam antibiotic
- prevent cross-linking of peptidoglycan cell walls (gram +/-)
-
context: bacterial treatment (Munson)
Metronidazole
- O2 requirements
- reduced by the pyruvate:ferredoxin oxidoreductase system (cytochromes in ETC)
- toxic to DNA = anaerobic in mitochondria
-
context: bacterial treatment (Munson)
Gentamicin
- aminoglycosides - protein synthesis inhibitors
- binds bacterial 16S(small) subunit and prevents ribosomal translocation
-
context: bacterial treatment (Munson)
streptomycin
- aminoglycosides - protein synthesis inhibitors
- binds bacterial 16S(small) subunit and prevents ribosomal translocation
-
context: bacterial treatment (Munson)
clindamycin
- lincosamides - protein synthesis inhibitors
- binds bacterial 23S(large) subunit and prevents ribosomal translocation
-
context: protozoal treatment: Malaria (Munson)
primaquine phosphate
- hepatic stages
- attack ETC of parasite
-
context: protozoal treatment: Malaria (Munson)
chloroquine phosphate
- blood stages
- prevents biocrystallization of heme (hemozeme..)
-
context: protozoal treatment: Malaria (Munson)
mefloquine (Lariam)
- blood stages
- phospholipid uptake (cell membrane)
-
context: protozoal treatment: Malaria (Munson)
atovaquone + proguanil (Malarone)
- atovaquone = inhibits ATP and nucleic acid synthesis
- proguanil = inhibits dihydrofolate reductase (shut down DNA replication)
-
context: protozoal treatment: Giardiasis (Munson)
Metronidazole (Flagyl)
reduced by the pyruvate:ferredoxin oxidoreductase system
-
context: protozoal treatment: Giardiasis (Munson)
Nitazoxanide (Alinia)
INHIBITS the pyruvate:ferredoxin oxidoreductase system
-
context: protozoal treatment: Giardiasis (Munson)
Albendazole (Albenza)
inhibits tubulin assembly into microtubules (stop it's movement)
-
context: fungal treatment: yeast (Munson)
fluconazole (Diflucan)
- oral
- inhibits 14 alpha demethylase = prevents ergosterol synthesis
-
context: fungal treatment: yeast (Munson)
ticonazole (Monistat)
- topical
- inhibits 14 alpha demethylase = prevents ergosterol synthesis
-
context: fungal treatment: yeast (Munson)
nystatin
- oral
- binds to ergosterol = ergosterol aggregation in cell membrane (leaky)
-
context: fungal treatment: mold (Munson)
fluconazole
- oral
- inhibits 14 alpha demethylase = prevents ergosterol synthesis
-
context: fungal treatment: mold (Munson)
clotrimazole
- oral or topical
- inhibits 14 alpha demethylase = prevents ergosterol synthesis
-
context: fungal treatment: mold (Munson)
ketoconazole
- topical
- inhibits 14 alpha demethylase = prevents ergosterol synthesis
-
context: fungal treatment: mold (Munson)
butenafine
- topical
- inhibits squalene epoxidase = prevents ergosterol synthesis
-
context: fungal treatment: mold (Munson)
terbinafine
- oral or topical
- inhibits squalene epoxidase = prevents ergosterol synthesis
-
context: helminth treatment: tapeworm (Munson)
albendazole (Albenza)
- intestinal
- inhibits tubulin assembly into microtubules (inhibit glucose uptake = starvation)
- inhibits helminth specific fumarate reductase
-
context: helminth treatment: tapeworm (Munson)
praziquantel (Biltricide)
- intestinal
- increases calcium permeability - interfere with neurological function = spasms
- decreases adenine uptake - no purines
-
context: helminth treatment: tapeworm (Munson)
albendazole (Albenza)
- cystic
- inhibits tubulin assembly into microtubules (inhibit glucose uptake = starvation)
- inhibits helminth specific fumarate reductase
-
context: helminth treatment: hookworm (Munson)
mebendazole (Vermix)
blocks uptake of glucose = starvation
-
context: helminth treatment: hookworm (Munson)
mebendazole
ascarisis (Ascarid infections)
-
context: helminth treatment: hookworm (Munson)
albendazole
ascarisis (Ascarid infections)
-
context: helminth treatment: pinworm (Munson)
mebendazole
enterobiasis
-
context: helminth treatment: pinworm (Munson)
albendazole
enterobiasis
-
context: helminth treatment: pinworm (Munson)
pyrantel pamoate
- enterobiasis
- depolarizing neuromuscular blocking agent = paralysis
-
context: virus treatment: Orthomyxoviruses -Influenza (Munson)
oseltamivir (Tamiflu)
neuraminidase inhibitor = prevents budding by interfering of virus = can't infect other cells
-
context: virus treatment: Orthomyxoviruses -Influenza (Munson)
zanamivir (Relenza)
neuraminidase inhibitor = prevents budding by interfering of virus = can't infect other cells
-
context: virus treatment: Orthomyxoviruses -Influenza (Munson)
amantadine (Symmetrel)
- adamantanes
- M2 ion channel blocker = prevents viral uncoating = can't get DNA out of capsid
-
context: virus treatment: Orthomyxoviruses -Influenza (Munson)
rimantadine (Flumadine)
- adamantanes
- M2 ion channel blocker = prevents viral uncoating = can't get DNA out of capsid
-
context: virus treatment: Retroviruses -HIV (Munson)
enfuvirtide (Fuzeon)
inhibit entry (inhibit receptor specificity)
-
context: virus treatment: Retroviruses -HIV (Munson)
lamivudine
- nucleoside/nucleotide analogues
- inhibits reverse transcriptase (INHIBIT RNA-->DNA)
-
context: virus treatment: Retroviruses -HIV (Munson)
zidovudine (Combivir)
- nucleoside/nucleotide analogues
- inhibits reverse transcriptase (INHIBIT RNA-->DNA)
-
context: virus treatment: Retroviruses -HIV (Munson)
efavirenz (Sustiva)
- RT binding agents
- inhibits reverse transcriptase (INHIBIT RNA-->DNA)
-
context: virus treatment: Retroviruses -HIV (Munson)
atazanavir (Reyataz)
inhibit maturation
-
context: virus treatment: Retroviruses -HIV (Munson)
ritonavir (Norvir)
inhibit maturation
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