Pharm Gout and RA

  1. What is the pharmacologic intervention for asymptomatic hyperuricemia?
    Nothing
  2. What is the pharmacologic intervention for acute gout?
    • NSAIDs
    • Colchicine
    • Glucocorticoids
  3. What is the pharmacologic intervention for intercritical phase of gout?
    Nothing
  4. What is the pharmacologic intervention for chronic gout?
    • Allopurinol
    • Febuxostat
    • Probenecid
    • Lesinurad
    • Pegloticase
  5. What are the 3 stages of managing gout?
    • 1) Treat acute attack
    • 2) Provide prophylaxis to prevent acute flares
    • 3) Chronic therapy involves lowering excess stores of urate to prevent flares and deposition of urate crystals
  6. When is steroid injection appropriate for treatment of gout?
    When comorbidities limit the use of NSAIDs or colchicine and/or large joint involved
  7. What are the anti-inflammatory drug dosages for different stages of gout?
    • High does for acute attacks
    • Lower doses to prevent recurrent attacks / therapeutic
  8. What is the mechanism of action for colchcine?
    Inhibits or halts cell division by interfering with microtubules
  9. What is the mechanism of action of allopurinol?
    Xanthine oxidase inhibitor
  10. What is the mechanism of action of febuxostat?
    Xanthine oxidase inhibitor
  11. What are the xanthine oxidase inhibitors drugs to treat hyperuricemia?
    • Allopurinol
    • Febuxostat
  12. What are uricosurics drugs to treat hyperuricemia?
    • Probenicid
    • Lesinurad
  13. What type of drug is Probenicid and what is its function?
    Uricosurics to treat hyperuricemia, increase uric acid and excretion in urine by blocking renal tubular transporter of uric acid, decreasing reabsorption of uric acid
  14. What type of drug is Lesinurad and what is its function?
    Uricosurics to treat hyperuricemia, increase uric acid and excretion in urine by blocking renal tubular transporter of uric acid, decreasing its reabosroption
  15. What are the uricases durgs to treat hyperuricemia?
    • Rasburicase
    • Pegloticase
  16. What type of drug is Rasburicase?
    Uricases to treat hyperuricemia, that converts uric acid to highly soluble allantoin
  17. What type of drug is pegloticase?
    Uricases to treat hyperuricemia, that converts uric acid to highly soluble allantoin
  18. What is the most common adverse event of initiation of serum urate-lowering therapy?
    Acute gout flare precipitated by changes in serum and tissue uric acid levels
  19. What should be done before initiation of serum urate-lowering treatment for prophylaxis of acute gout?
    Anti-inflammatory therapy, about 1-2 weeks prior, and continue for 6 months until trophi resolves
  20. What is a side effect of using allopurinol or febuxostat on patient who is taking azathioprine and 6-meracptopurine?
    Bad things will happen because those are immunosuppressant and allopurinol/ febuxostat prolong the half-life
  21. What is DMARDs and what is the goal of using these drugs?
    • Disease modifying anti rheumatic drugs;
    • Prevent or control joint damage and prevent loss of function + decrease pain
  22. What is the name stem for monoclonal antibody drugs?
    -mab
  23. What is the name stem for fusion protein drugs?
    -cept
  24. What is the name stem for kinase inhibitor drugs?
    -nib
  25. What is the mechanism of action of methotrexate?
    • Folic acid antagonize. Antineoplastic MOA by inhibiting dihydrofolate reductase thereby inhibit DNA and RNA synthesis
    • Proposed to inhibit T cell proliferation. Promite the release of adenosine- an anti-inflammatory mediator
  26. What is the mechanisms of action of adalimumab?
    TNF receptor inhibition
  27. What is the mechanism of action of infliximab?
    TNF receptor inhibition
  28. What is the mechanism of action of etanercept?
    TNF receptor inhibition
  29. What is the mechanism of action of tofacitnib?
    Kinase inhibitor
  30. What is concerning about the use of anti-TNF DMARDs?
    Increased risk for TB and fungal infections
  31. True/False: NSAIDs are disease-modifying drug?
    False
Author
lykthrnn
ID
343200
Card Set
Pharm Gout and RA
Description
NMSK Exam 2 Pharm
Updated