Pharm Daptomycin/Linezolid

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What is the mechanism of action for Daptomycin?

Alteration of cell-membrane permeability by binding to bacterial membrane and causing rapid depolarization of membrane potential resulting in inhibition of protein, DNA and RNA synthesis
What bacteria do daptomycin target?

Gram positive organisms
Do daptomycin have activity against Gram-negative organisms?

No
What happens to daptomycin when it binds to lung surfactant and is it effective for PNA?

Inactivate it and not effective for pneumonia
Is daptomycin okay to give to someone with beta lactam allergy?

Yes
How is daptomycin eliminated?

Renal elimination
Can daptomycin be given orally? What is the common mode of administration?

Not orally, only IV
What are adverse effects of daptomycin?

Causes myopathy with increased creatine phosphokinase
What is the mechanism of action of action for linezolid?

Inhibition of protein metabolism
What is the antibactieral spectrum for linezolid?

Gram positive bacteria: GAS (streptococcus), pneumococci, MSSA, MRSA, Enterococci/VRE
Does Linezolid have Gr negative activity?

No
What is the common modes of administration for linezolid?

IV and PO
Is Linezolid okay to give to people with beta lactam allergy?

Yes
What are the adverse effects of linezolid?
- Reversible bone marrow suppression
- Serotonin syndrome
What is serotonin syndrome?

High levels of serotonin when linezolid given to patients who are also on serotonergic psych meds
What are the symptoms of serotonin syndrome?
- Mental changes including confusion, hyperactivity, memory problems
- Muscle twitching
- Excessive sweating
- Shivering or shaking
- Diarrhea
- Trouble with coordination
- fever
Is Daptomycin good against MRSA?

Yes
Is linezolid good against MRSA?

Yes
What are the specific antimicrobial therapy for methicillin-susceptible Staph aureus (MSSA)?
- Nafcillin
- Oxacillin
- Flucloxacillin
What is an alternative regimen for MSSA?
- Cefazolin
- Ceftriaxone
What is the specific antimicrobial therapy for MRSA?

Vancomycin
What are alternative regimen for MRSA?
- Daptomycin
- Linezolid
What happens with septic arthritis caused by Staph aureus complicated by bacteremia?

Treatment prolonged to 4 weeks because of metastitc seeding
Treating regimen for N. gonorrhoeae
- Ceftriaxone
- Azithromycin

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Pharm Daptomycin/Linezolid

Description

NMSK Exam 2 Pharm

Updated

2018-10-26T06:29:46Z

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