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The establishment & growth of a microorganism on or in a host
an Infection
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refers to the policies followed by heath care workers that help prevent the spread of disease
Infection control
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are those acquired in the course of medical care
Nosocomial infections
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nosocomial infections has increased over the past few decades, why?
the emergence of new diseases & an increase in organisms becoming resistant to antibiotics
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(Main factors that increase the chance of nosocomial infection:)
Other patients that have diseases, visitors, contaminated food or medical equipment, the air circulation, & the medical personnel who care for the patient
Environment
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(Main factors that increase the chance of nosocomial infection:)
The type of drugs the patient is taking. Although certain drugs help kill infections, they may alter the normal flora within the body or depress the immune system. This leads to a decreased resistance to other type s of hospital germs.
Therapeutic Regimen
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(Main factors that increase the chance of nosocomial infection:)
Instruments & equipment that have not been adequately cleaned & sterilized
Equipment
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(Main factors that increase the chance of nosocomial infection:)
Microorganisms transmitted through medical procedures if correct technique not used
Contamination
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(The ability to resist infection depends on the following factors:)
The very young who have immature immune systems & the elderly who have immune systems that are less efficient, both have difficulty in fighting off infection
Age
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(The ability to resist infection depends on the following factors:)
Genetic factors & congenital conditions make individuals more or less resistant to infection
Heredity
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(The ability to resist infection depends on the following factors:)
Inadequate nutrient intake or an over abundance of intake (obesity), decrease resistance to infection
Nutrition status
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(The ability to resist infection depends on the following factors:)
Physiological & psychological stress increase certain hormone (cortisone) production, thereby lowering resistance to infection
Stress
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(The ability to resist infection depends on the following factors:)
Lack of sleep and/or exercise decrease blood circulation & lowers resistance to infection
Inadequate rest & exercise
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(The ability to resist infection depends on the following factors:)
Those with chronic conditions such as diabetes & heart disease are at a greater risk for infection, as are those not immunized
Health history
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(The ability to resist infection depends on the following factors:)
Persons with broken skin, burns, or who have had trauma are more susceptible to infection, as are those who have a suppressed immune system due to medication
Inadequate defenses
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(The ability to resist infection depends on the following factors:)
Smoking, drug & alcohol use, & certain sexual practices all affect the ability of the body to fight off infection
Personal habits
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is a tiny form of life found in the environment & within all living things (plants, animals, & humans).
Microorganism (Live in the air, on land, & in the water)
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Microorganisms that cause disease are called
Pathogens
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Main types of pathogens
- - Bacteria
- - Viruses
- - Fungi
- - Parasites
- - Prions
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Microscopic one-celled organisms with a typical nucleus
Bacteria
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bacteria that can survive in an oxygen environment
aerobes
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bacteria that cannot survive in an oxygen environment
anaerobes
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Beneficial bacteria
Probiotics: (lactobacillus & bifidobacterium)
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- Tuberculosis (TB)
- Streptococcal (strep infections)
- Staphylococcal (wound infections)
- Salmonella (food poisoning)
- Gonorrhea & syphilis (venereal diseases)
- Tetanus (lockjaw)
Bacterial Diseases
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Smallest, microscopic non-cellular organisms
viruses
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Do viruses contain DNA, RNA, or Both?
Either DNA or RNA
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Must invade a host cell to survive & reproduce
viruses
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process of virus
viral particle (virion) attaches to host cell & inserts its own genetic information. Then redirects host cell to produce new viruses.
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- Common cold (rhinovirus)
- Influenza (flu)
- Measles (rubeola)
- Mumps (parotitis)
- Rubella (German measles)
- Hepatitis A, B, C, D, & E
- HIV (causes AIDS)
- HSV I (cold sores)
- HSV II (genital herpes
Viral Diseases
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Multicellular (molds) or one-celled organisms (yeasts) with a nucleus & membrane-bound organelles
Fungi
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Mold:
Aspergillus (allergic reactions & asthma)
Yeast:
Candida Albicans (vaginal/intestinal yeast infection or in the mouth - "thrush")
Dimorphic:
Histoplasmosis (fungus contracted from bird & bat droppings & in soil)
Tinea (ringworm) & tinea pedis (athlete’s foot)
Fungal Diseases
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Organisms that live on or in a host organism and get their food from or at the expense of the host
Parasites
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three main classes of parasites that can cause disease in humans:
- - Protozoa
- - Helminths
- - Ectoparasites
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One-celled complex microorganisms that have mobility through:
Pseudopod formation – part of cell presses forward & the rest follows
Flagella – whip-like projections (like a tail)
Cilia – small, delicate hair-like projections
Protozoa
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- Malaria (fever; spread by mosquitoes)
- Giardiasis (intestinal; contaminated H2O & feces)
- Toxoplasmosis (“Cat Scratch Fever”; flu-like symptoms; dangerous in pregnancy; animal feces & contaminated food & H2O )
Protozoa Diseases
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Parasitic worms:
- Flatworms & roundworms
- Found primarily in human intestinal tract
helminths
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- Enterobiasis (pinworm; feces)
- Trichinosis (contaminated H2O & undercooked meat such as pork, bear, horse, venison)
- Diphyllobothrium latum (tapeworm; contaminated food or H2O
types of helminths diseases
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Organisms such as ticks, fleas, lice, and mites that attach or burrow into the skin and remain there for relatively long periods of time (e.g., weeks to months)
Ectoparasites
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- Scabies (mites - itching & rash)
- Lice (head & pubic – the “crabs”)
- Lyme disease (ticks – rash, muscle aches, fever)
ectoparasite diseases
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Mutated form of a normal protein found mostly in the central nervous system (Do not contain DNA or RNA)
Prions
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- Transmissible spongiform encephalopathies (TSE) which are fatal neurodegenerative diseases in animals & humans
- Creutzfeldt-Jakob ("Mad-Cow") disease is the most common disease resulting from infection with prions. It is transmitted to humans by eating infected meat.
Prion Diseases
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ability to cause disease
pathogenicity
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ability to grow & multiply with speed
virulence
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ability to enter tissues
invasiveness
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attraction to a particular host
specificity
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A "_____" or environment for the microbes to live & multiply - living or not: human, animal, plant, water, food earth.
resevoir
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A person who serves as a reservoir is called a "_____".
carrier
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4 means of infection transmission are?
- 1. Direct contact
- 2. Indirect contact
- 3. Droplet contact
- 4. Airborne route
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an infected person directly touches another or their blood & body fluids (shaking hands, kissing, sexual intercourse, or being injected with their blood)
direct contact
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a person touches objects (fomites) contaminated by an infected person (clothing, dishes, utensils, surgical dressings or instruments)
indirect contact
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pathogens come in contact with the eyes, nose or mouth of a person through a cough, sneeze, & when talking (can travel 3-5 feet!)
droplet contact
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a person inhales residue from evaporated droplets of diseased microorganisms
airborne route
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are protein chemical markers that identify cells.
antigens
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are proteins produced by B cells (a particular type of lymphocyte/WBC) in response to foreign antigens.
antibodies
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is when our body produces its own antibodies.
active acquired immunity
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is when antibodies are received from another person or animal.
passive acquired immunity
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