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HA-MRSA (14)
vancomycin, daptomycin, linezolid, tedizolid, ceftaroline, delafloxacin, telavancin, dalbavancin, oritavancin, tigecycline, teciplanin, quinapristin/dalfopristin (Synercid), chloramphenicol, rifamin in combo
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CA-MRSA (8)
sulfamethoxazole/trimethoprim (Bactrim), doxycycline, minocycline, clindamycin, linezolid, tedizolid, delafloxacin, moxifloxacin (not used)
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pseudomonas (15)
pipercillin/tazobactam (Zosyn), ceftazidime (Fortaz), ceftazidime/avibactam (Avycaz), ceftolozane/tazobactam (Zerbaxa), cefipime (Maxipime), aztreonam (Azactam), ciprofloxacin, levofloxacin, delafloxacin, imipenem/cilastatin (Primaxin), meropenem, meropenem/vaborbactam (Vabomere), doripenem, aminoglycoside (gentamicin, tobramycin, amikacin), colistin
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VRE (8)
linezolid, tedizolid, daptomycin, oritavancin, tigecycline, quinupristin/dalfopristin (Synercid), teicoplanin, telavancin
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NO renal adjustment (10)
nafcillin, oxacillin, ceftriaxone, clindamycin, azithromycin, erythromycin, moxifloxacin, doxycyline, tigecycline, rifampin
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time-dependent antibiotics
- keep it above the MIC! = C1V1
- ALL beta lactams (penicillins, cephalosporins, carbapenems, aztreonam), vancomycin
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concentration-dependent antibiotics
- make a high peak! AUIC
- Fluoroquinolones and aminoglycosides
- has post antibiotic effect ... even below the MIC, it kills/inhibits growth for a few hours likely d/t hitting the DNA/ribosomes and not just the cell wall
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