Antibiotics = fun

  1. HA-MRSA (14)
    vancomycin, daptomycin, linezolid, tedizolid, ceftaroline, delafloxacin, telavancin, dalbavancin, oritavancin, tigecycline, teciplanin, quinapristin/dalfopristin (Synercid), chloramphenicol, rifamin in combo
  2. CA-MRSA (8)
    sulfamethoxazole/trimethoprim (Bactrim), doxycycline, minocycline, clindamycin, linezolid, tedizolid, delafloxacin, moxifloxacin (not used)
  3. pseudomonas (15)
    pipercillin/tazobactam (Zosyn), ceftazidime (Fortaz), ceftazidime/avibactam (Avycaz), ceftolozane/tazobactam (Zerbaxa), cefipime (Maxipime), aztreonam (Azactam), ciprofloxacin, levofloxacin, delafloxacin, imipenem/cilastatin (Primaxin), meropenem, meropenem/vaborbactam (Vabomere), doripenem, aminoglycoside (gentamicin, tobramycin, amikacin), colistin
  4. VRE (8)
    linezolid, tedizolid, daptomycin, oritavancin, tigecycline, quinupristin/dalfopristin (Synercid), teicoplanin, telavancin
  5. NO renal adjustment (10)
    nafcillin, oxacillin, ceftriaxone, clindamycin, azithromycin, erythromycin, moxifloxacin, doxycyline, tigecycline, rifampin
  6. time-dependent antibiotics
    • keep it above the MIC! = C1V1
    • ALL beta lactams (penicillins, cephalosporins, carbapenems, aztreonam), vancomycin
  7. concentration-dependent antibiotics
    • make a high peak! AUIC
    • Fluoroquinolones and aminoglycosides
    • has post antibiotic effect ... even below the MIC, it kills/inhibits growth for a few hours likely d/t hitting the DNA/ribosomes and not just the cell wall
Author
VASUpharm14
ID
341765
Card Set
Antibiotics = fun
Description
TLDR stuff
Updated