Triad of pheochromocytoma
- Profuse sweating, palpitations, headache
- Triad DOES NOT include Hypertension
Tumor Lysis Syndrome consists of
- Renal Failure
Dx of carcinoid syndrome
- Urinary Metabolites of tryptophan and serotonin which include 5HIAA, 5HT, 5HTP
- Typical carcinoid: 5HIAA
- Atypical carcinoid: 5HTP
- Urinary metanephrines more sensitive than VMA
- Specificity of both is equal
- Hypokalemic Metabolic alkalosis with hypercalciuria (Nephrocalcinosis)
- Normal BP
Harrison: Hypokalemic Metabolic Alkalosis with normal BP may be seen in both Bartter’s and Gitelman’s syndrome. Presence of Nephrocalcinosis from increased urinary excretion of calcium is typically seen in Bartter’s syndrome and distinguishes Bartter’s from Gitelman’s syndrome (decreased urinary calcium excretion). If with hypokalemic metabolic alkalosis there is Hypertension, one should suspect Liddle’s syndrome.
About platelets transfusion
Do not carry Rh antigen
- Platelets bear both intrinsic and adsorbed antigen of the ABO system.
- The clinical importance of ABO compatibility in platelet transfusion is controversial.
- Transfusion of ABO incompatible platelets may be associated with decreased post-transfusion platelet recovery and normal survival.
AML-M3 predisposes to DIC
- Auer rods are capable of activating coagulation cascade
- Characteristic cell present in this stage is called faggot cell (faggot meaning bundle of sticks)
- Faggot cell has tons of auer rods in it (30-40)
- Pathognomonic for this type of AML
AML M1, 2, 4, 5,6 may have auer rods in neutrophilic lineage cells (myeloblasts) but absent in monocytic precursors (monoblasts) or erythroblasts.