RBC Physiology & O2 Curves

More O2 is released for any given drop in pressure

Less O2 will be released at any given drop in pressure

• 60% phospholipid
• 30% cholesterol
• 10% glycolipid

• Integral proteins also included are: 
• band 3 glycoprotein
• sialoglycoproteins
• Rh (D) protein

• Spectrin
• Actin
• Ankyrin

Describes the relationship between hydrogen ions and oxygen affinity:

An increase in H+ (low pH) shifts curve to right

A decrease in H+ (high pH) shifts curve to the left

CO2 effects Hgb O2 affinity independent of its effect through pH. 

See slide 12? physiology, composition, & function

Inorganic ions such as Cl interact with certain positively charged sites on the Hgb molecule and alter O2 affinity. 

Chloride decreases = O2 affinity & Bohr effect increase

Strong affinity fro reduced Hgb, which causes Hgb to release O2 to the tissues and binding to reduced Hb

This molecule is present in equal concentrations with Hgb.

Increased body temp = Shift to the right = release of O2 to tissue

Decreased body temp = Shift to the left = Less O2 released to tissue