Multiple Sclerosis

  1. What is MS, who does it affect and progression:
    • Autoimmune disorder of the CNS
    • Caused by activation of T helper and T killer cells against myelin sheath that surrounds and insulates nerve fibers, with a corresponding decrease in regulatory T cells.
    • Demyelination causes nerve impulses to be slowed or halted and produces the symptoms of MS.

    • 80% people have relapsing/remitting clinical course of episodic dysfunction of CNS → variable recovery
    • 20% people have slowly progressive clinical course

    • Small minority have a quick progression leading to early death
    • Peak onset = 30’s
    • Symptoms come on over days/weeks and resolve over weeks/months
    • Some have single episode of optic neuritis
    • 15% don’t suffer more than 1 episode
    • Average 1-2 relapses every 2 yrs
    • 5% die within 5 yrs of onset
    • 30% are disabled needing help walking after 10 yrs
    • Intellectual impairment uncommon until late in disease progression
  2. S&S
    • Optic neuropathy - Blurring of vision (1eye) develops slowly can lead to severe loss of vision but generally recovery is in 1-2 months.
    • Coordination
    • Balance
    • Speech
    • Loss of feeling
    • Bladder symptoms – may need self catheterization
    • Weakness in one or both hands or legs
    • Others: Trigeminal neuralgia, loss of balance and vertigo, fatigue
  3. Causes and Risk factors:
    • Poor control of inflammatory processes/ immune system (Autoimmunity / Increased tissue necrosis factor (TNF))
    • Infection: Viral - EBV, measles, herpes, corona virus, parainfluenza virus. Bacterial-borrelia spirochaete from tick
    • Heavy metal exposure – copper, mercury
    • Possible blood brain barrier abnormalities due to excessive platelet adhesiveness and aggregation
    • Diet high in saturated animal fat
    • Number of genetic factors – genetically predisposed to high BMI or low vitamin D levels (MS is more common in latitudes further away from the equator)
  4. Diagnosis and treatment:
    • Symptomatic treatment for acute relapse - High dose IV corticosteroids to reduce inflammation.
    • Prevention of future relapses - Immunosuppressive agents which kill white blood cells that attack myelin. 
    • B-interferons which decrease inflammation
    • Physiotherapy & Occupational therapy
  5. Nutritional Protocol and supplements:
    • SWANK diet LOW SAT FAT – less than 15g/d
    • No processed foods containing sat fat/hydrogenated oils
    • No RED MEAT for first year, including Pork (after first year, 80g/week)
    • White skinless poultry and fish (but avoid fatty fish to 50g/d and avoid dark poultry)
    • No egg yolks
    • Wholegrain fruit and veg
    • (Anna likes associating, Dark, Black, East London, Cocaine loving oyk)
    • ALA
    • Vit D3 2000 IU/d – promotes T cell differentiation into T-reg cells, immunomodulatory
    • B12 1000mcg/day – remyelination, immunomodulatory, repair
    • Vitamin E
    • Cod Liver Oil – highly unsaturated fatty acids, high in Vit D and A
    • Turmeric/curcumin - T-cell modulation and anti-inflammatory effects EGCG - decreased Th1 and Th17, and increased Treg cells.
  6. Wahls protocol:
    • 3 CUPS OF LEAFY GREENS contain vitamins A, C, K, B and minerals that help protect the brain cells Excellent sources of these vitamins and minerals include kale and parsley.
    • 3 CUPS OF SULPHUR-RICH VEGETABLES Since sulphur compounds help with cellular detoxification and the creation of neurotransmitters
    • 3 CUPS OF COLOURFUL FRUITS AND VEGETABLES Colourful fruits and vegetables are loaded with antioxidants that can help combat oxidative activity in MS damage.
    • GRASS-FED MEAT AND ORGAN MEATS excellent source of vitamins, minerals, and CoQ10.
    • SEAWEED The high amounts of iron, calcium, and fibre found in seaweed help to increase alertness and mental clarity, especially in MS patients.
Card Set
Multiple Sclerosis
Multiple Sclerosis