What is MS, who does it affect and progression:
- Autoimmune disorder of the CNS
- Caused by activation of T helper and T killer cells against myelin sheath that surrounds and insulates nerve fibers, with a corresponding decrease in regulatory T cells.
- Demyelination causes nerve impulses to be slowed or halted and produces the symptoms of MS.
- 80% people have relapsing/remitting clinical course of episodic dysfunction of CNS → variable recovery
- 20% people have slowly progressive clinical course
- Small minority have a quick progression leading to early death
- Peak onset = 30’s
- Symptoms come on over days/weeks and resolve over weeks/months
- Some have single episode of optic neuritis
- 15% don’t suffer more than 1 episode
- Average 1-2 relapses every 2 yrs
- 5% die within 5 yrs of onset
- 30% are disabled needing help walking after 10 yrs
- Intellectual impairment uncommon until late in disease progression
- Optic neuropathy - Blurring of vision (1eye) develops slowly can lead to severe loss of vision but generally recovery is in 1-2 months.
- Loss of feeling
- Bladder symptoms – may need self catheterization
- Weakness in one or both hands or legs
- Others: Trigeminal neuralgia, loss of balance and vertigo, fatigue
Causes and Risk factors:
- Poor control of inflammatory processes/ immune system (Autoimmunity / Increased tissue necrosis factor (TNF))
- Infection: Viral - EBV, measles, herpes, corona virus, parainfluenza virus. Bacterial-borrelia spirochaete from tick
- Heavy metal exposure – copper, mercury
- Possible blood brain barrier abnormalities due to excessive platelet adhesiveness and aggregation
- Diet high in saturated animal fat
- Number of genetic factors – genetically predisposed to high BMI or low vitamin D levels (MS is more common in latitudes further away from the equator)
Diagnosis and treatment:
- Symptomatic treatment for acute relapse - High dose IV corticosteroids to reduce inflammation.
- Prevention of future relapses - Immunosuppressive agents which kill white blood cells that attack myelin.
- B-interferons which decrease inflammation
- Physiotherapy & Occupational therapy
Nutritional Protocol and supplements:
- SWANK diet LOW SAT FAT – less than 15g/d
- No processed foods containing sat fat/hydrogenated oils
- No RED MEAT for first year, including Pork (after first year, 80g/week)
- White skinless poultry and fish (but avoid fatty fish to 50g/d and avoid dark poultry)
- No egg yolks
- Wholegrain fruit and veg
- (Anna likes associating, Dark, Black, East London, Cocaine loving oyk)
- Vit D3 2000 IU/d – promotes T cell differentiation into T-reg cells, immunomodulatory
- B12 1000mcg/day – remyelination, immunomodulatory, repair
- Vitamin E
- Cod Liver Oil – highly unsaturated fatty acids, high in Vit D and A
- Turmeric/curcumin - T-cell modulation and anti-inflammatory effects EGCG - decreased Th1 and Th17, and increased Treg cells.
- 3 CUPS OF LEAFY GREENS contain vitamins A, C, K, B and minerals that help protect the brain cells Excellent sources of these vitamins and minerals include kale and parsley.
- 3 CUPS OF SULPHUR-RICH VEGETABLES Since sulphur compounds help with cellular detoxification and the creation of neurotransmitters
- 3 CUPS OF COLOURFUL FRUITS AND VEGETABLES Colourful fruits and vegetables are loaded with antioxidants that can help combat oxidative activity in MS damage.
- OMEGA-3 FATTY ACIDS
- GRASS-FED MEAT AND ORGAN MEATS excellent source of vitamins, minerals, and CoQ10.
- SEAWEED The high amounts of iron, calcium, and fibre found in seaweed help to increase alertness and mental clarity, especially in MS patients.